This study has developed a method to prepare diastereo‐ and regio‐selective indoline‐fused 2,5‐diketopiperazine scaffolds. The synthetic process involved an Ugi four‐component reaction in which readily available starting materials were used and a metal‐free intramolecular post‐Ugi tandem consecutive 5‐exo‐trig/6‐exo‐dig cyclization under basic conditions. The plausible mechanism and substrate structures were elucidated by single‐crystal X‐ray diffraction analysis and supported by density functional theory calculations.
Background: Dengue is a viral disease transmitted to humans by the bite of infested females of the main vector Aedes aegypti and to lesser extent Aedes albopictus mosquitoes.Knowledgeregardingdenguefever(DF)isveryimportantamongstudents to create awareness for practicing the prevention and increase the student’s attitude levels. Objective: To assess the knowledge, attitude and practice regarding Dengue Fever among University Students. Methods: The study design was cross-sectional design. This study was conducted in at nine campuses in two states in Malaysia. A purposive sampling technique was used of 1144 students who residing in this public university collegesfrom the selected setting and willing to participate in the study. Self-administered questionnaire consisted of four sections, socio-demographic profile, the knowledge, attitude and practice related to dengue/ mosquito control. The data were entered and analyzed using IBM Statistical Packages for Social Science (SPSS) for Window, version 23 and descriptive analyses were executed for each variable. Results: In total, 74% of the participants were female and 26% male, ages ranged from 18 to 39 years. Overall 97.8% of them ever heard of DF and the predominant source of the information was media (86.4%). Fever, joint pains and headache was well known as a symptom of DF for most of students. They knew that Aedes mosquitoes transmit DF(94.8%)andstagnantwateristhemainsourceformosquitobreeding(94.8%).Many participants aware that removal of stagnant water (89.2%), using mosquito repellents (88.9%),tightlycoveringwatercontainers(86%)andtheuseofwindowsscreenandbed nets (82.5%) able to prevent mosquito breeding and reduced contact with mosquitoes. Consulting a physician for DF (92.7%), taking plenty of rest (86.1%) and drink plenty of water (81.4%) was the best management for DF. Most of the students agreed (97.3%) that dengue is a serious illness. They agreed that communities should actively participate in controlling the vectors of dengue virus (94.7%) in which controlling the breeding places of mosquitoes, a good strategy to prevent DF (97.5%). Thus, this study revealed that the respondents had perceived inadequate knowledge (85.0%), poor attitude (58.0%) and poor practice (88.0%) of Dengue fever. Conclusion: In conclusion, although this study discovered that the students’ had basic knowledge, aware of the seriousness of the disease and practiced some level of prevention related to DF but the needs of educational programs adapting transformational learning and strategies by the university such as developing student’s friendly and continuous information regardingDFaspartofhealthpromotionstrategiesandtheneedsofholisticapproach, community participation and cooperation is important to impart knowledge and foster good practices in the prevention and controlling of dengue not only in the campus but trigger good practice among the community in general.
The hitherto elusive monobridged Ge(μ‐H)GeH (X1A′) molecule was prepared in the gas phase by bimolecular reaction of atomic germanium with germane (GeH4). Electronic structure calculations revealed that this reaction commenced on the triplet surface with the formation of a van der Waals complex, followed by insertion of germanium into a germanium‐hydrogen bond over a submerged barrier to form the triplet digermanylidene intermediate (HGeGeH3); the latter underwent intersystem crossing from the triplet to the singlet surface. On the singlet surface, HGeGeH3 predominantly isomerized through two successive hydrogen shifts prior to unimolecular decomposition to Ge(μ‐H)GeH isomer, which is in equilibrium with the vinylidene‐type (H2GeGe) and dibridged (Ge(μ‐H2)Ge) isomers. This reaction leads to the formation of cyclic dinuclear germanium molecules, which do not exist on the isovalent C2H2 surface, thus deepening our understanding of the role of nonadiabatic reaction dynamics in preparing nonclassical, hydrogen‐bridged isomers carrying main group XIV elements.
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