Anatoxin-a (ATX-a) is a neurotoxic alkaloid, produced by several freshwater planktonic and benthic cyanobacteria (CB). Such CB have posed human and animal health issues for several years, as this toxin is able to cause neurologic symptoms in humans following food poisoning and death in wild and domestic animals. Different episodes of animal intoxication in the wild have incriminated ATX-a, as confirmed by the presence of ATX-a-producing CB in the consumed water or biofilm and/or the observation of neurotoxic symptoms, which match experimental toxicity in vivo.Regarding toxicity parameters, toxicokinetics knowledge is currently incomplete and needs to be improved. The toxin is able to cross passively biological membranes and act rapidly on nicotinic receptors, its main molecular target. In vivo and in vitro acute effects of ATX-a have been studied and make possible to draw its mode of action, highlighting its deleterious effects on the nervous systems and its effectors, namely muscles, heart and vessels, and the respiratory apparatus. However, very little is known about its putative chronic toxicity. This review updates available data on ATXa, from the ecodynamic of the toxin to its physiological and molecular targets.

Toxicity, transfer and depuration of anatoxin-a (cyanobacterial neurotoxin) in medaka fish exposed by single-dose gavage Simon Colas (Investigation) (Formal analysis)Visualisation)Writing-originnal draft), Charlotte Duval (Resources), Benjamin Marie (Conceptualization) (Methodology) (Supervision) (Writing-review and editing) (Funding acquisition)