Objective: This study aimed to perform an expository review about the aging process of oral tissues, correlating the information available in the literature to a conceptual and terminological view. For this purpose, a search was performed in the literature with reference to SCIELO, MEDLINE and Health Portals databases. Methods: The methodology used was the bibliographic, an explanatory research, combined with a contextualization of the data, where the main intention was to make science in the scope of qualitative methods and techniques of research. Where the inclusion criteria were availability of the full text of the study, to demonstrate clarity in the methodological detail used and to be available in Portuguese or English. Conclusion: Through the perquirition performed in this study, it was possible to discuss in an enriching way the proposed theme, encompassing several physiological aspects, morphological and external characteristic, while main actors in the process of Oral senescence.
Oral carcinogenesis is a highly complex process. Molecular studies demonstrate that some oral cancers progress from pre-neoplastic lesions. Cancer stem cells (CSCs), a small cellular group within the tumor, have currently received much attention by its self-renewal and tumor differentiation ability. It is considered that CSCs may be responsible for the relapse and metastasis of cancer. CSCs have been reported to express common embryonic stem cells markers such as Nestin and Nanog. The aim of the present study was to identify the presence of Nestin and Nanog markers in patients with oral squamous cell carcinoma (OSCC). Nine samples were collected from patients diagnosed with OSCC and two healthy oral mucosa were used as control. The markers expression in nine OSCC was determined by end-point PCR. The OSCC population analyzed was mostly composed of black and white males, with a mean age of 70.6 years, that reported alcohol and tobacco consumption. Nestin and Nanog stem cell markers were expressed in all OSCCs and normal samples analyzed. As these two markers have already been related to the mechanism of metastasis and relapses in cancer, its expression determination could help to understand the aggressive and invasive nature of OSCC.
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