Ovariectomy induces an increase, estrogen treatment after ovariectomy a decrease, in the level at which female rats regulate their body weights. Food-intake changes are transient, intake returning toward normal values as terminal body weight is approached; so these intake changes are probably secondary to effects on the weight-regulating system itself. Adrenalectomy blocks or reverses the weight gain which follows ovariectomy. This effect is not a matter of incapacity, but seems to reflect a resetting of the weightregulating system so that a low weight level is voluntarily maintained.
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