A large portion of the chemical subspace is the multi‐component reaction (MCR). Apart from Domino reactions, MCR is one of the most promising routes for one‐pot synthesis. Thus, MCR derived product can be considered as a synthetic hub to a vast diversity of novel cyclic or acyclic compounds. Heterocyclic moiety such as naphthyridines, quinolines, dihydropyridines (DHPs), quinazolines, pyrimidines, imidazoles, diazepines, and spiro‐heterocycles are widely recognized in clinical evaluation. Because of their relevant significance, vast literature exists to accomplish the synthesis of these biologically important compounds. Therefore, this review highlights the last ten years of developments in the one‐pot synthesis of these heterocyclic moieties which are widely recognized by the industry in addition to academia.
An Efficient 'On-Water' Synthesis of 1,4-Dihydropyridines Using Fe 3O4@SiO2 Nanoparticles as a Reusable Catalyst. -The reaction fails using aliphatic aldehydes, ketones or furfuraldehyde. The catalyst is magnetically recycled and reused in four additional cycles with slightly diminishing yields. The products possess the core of a number of biologically relevant compounds. -(DAM, B.; NANDI, S.; PAL*, A. K.; Tetrahedron Lett. 55 (2014) 38, 5236-5240, http://dx.
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