A continuous-flow photocatalytic synthesis of the industrially important thiuram disulfides has been developed, utilizing O2 as the oxidant and Eosin Y as the photoredox catalyst.
A sustainable and atom-economic synthesis of the widely applied rubber accelerator tetramethylthiuram monosulfide (TMTM) from tetramethylthiuram disulfide (TMTD) is reported. Triphenylphosphite (TPPi) is employed as a green reductant to replace the traditionally used sodium cyanide, which causes severe safety risk due to its high toxicity. The new process proceeds smoothly under mild conditions, with excellent yield of TMTD. This single-step, one-pot method also has the potential of producing the industrially important lubricant additive triphenylthiophosphate (TPPT) as a high added-value by-product.
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