The permeability and diffusion of vitamin B-12 in chitosan, crosslinked chitosans, and chitosan/poly (vinyl alcohol) (PVA) blends were studied using "lag time" technique. Apparently the diffusion coefficient, D , for both crosslinked and blended chitosan membranes depends solely upon the equilibrium swelling ratio, Q, of the material in water. The functional dependence of D on Q was obtained from the data. The partition coefficients calculated for vitamin B-12 in all membranes studied were nearly constant ( K = 0.4). The results are shown to be consistent with the "pore type" transport mechanism for vitamin B-12 in these chitosan membranes.
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