Aspertetranones A-D (1-4), four new highly oxygenated putative rearranged triketide-sesquiterpenoid meroterpenes, were isolated from the marine algal-associated fungus Aspergillus sp. ZL0-1b14. On the basis of a comprehensive spectroscopic analysis, the planar structures of aspertetranones were determined to possess an unusual skeleton in the terpenoid part. The relative and absolute configurations of the aspertetranones were assigned on the basis of NOESY analysis, X-ray crystallography, and circular dichroism spectroscopy. Compounds 1-4 were evaluated for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages. Aspertetranone D exhibited an inhibitory effect against IL-6 production with 69% inhibition at 40 μM.
Three new compounds, an open-chain cytochalasan scoparasin C (1), a pyrichalasan scoparasin D (2), and a β-eudesmol type sesquiterpene scopararane C (5), along with three known compounds (3, 4 and 6), were isolated from the marine fungus Eutypella scoparia 1-15. Their structures were determined on the basis of comprehensive NMR and MS analysis. Compound 2 exhibited potent cytotoxicities with very low IC 50 values against several cancer cell lines, including A375, A549, HepG2 and MCF-7.
The first total synthesis of carbazole alkaloids lansine Fa nd clauemarazole Di sd escribed. The spectroscopic data of the synthetic molecules were identicalt ot hose dis-played by the natural products,t hus confirming the accuracy of the proposed structures.Supportinginformation for this article can be found under http:// dx.
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