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We propose six new benchmark scenarios for Higgs boson searches in the Minimal Supersymmetric Standard Model. Our calculations follow the recommendations of the LHC Higgs Cross Section Working Group, and benefit from recent developments in the predictions for the Higgs-boson masses and mixing. All of the proposed scenarios are compatible with the most recent results from Run 2 of the LHC. In particular, they feature a scalar with mass and couplings compatible with those of the observed Higgs boson, and a significant portion of their parameter space is allowed by the limits from the searches for SUSY particles and additional Higgs bosons. We define a scenario where all SUSY particles are relatively heavy, and two scenarios with light colorless SUSY particles (charginos, neutralinos and, in one case, staus). In addition, we present two scenarios featuring alignment without decoupling, realized with either the lighter or the heavier scalar being SM-like, and a scenario with CP violation.

Rapidly reversible, sedation-related delirium does not signify the same poor prognosis as persistent delirium. Degree of sedation should be considered in delirium assessments. Coordinating delirium assessments with daily sedative interruption will improve such assessments' ability to prognosticate ICU delirium outcomes. Clinical trial registered with www.clinicaltrials.gov (NCT 00919698).

Sedation and analgesia are important components of care for the mechanically ventilated patient in the intensive care unit (ICU). An understanding of commonly used medications is essential to formulate a sedation plan for individual patients. The specific physiological changes that a critically ill patient undergoes can have direct effects on the pharmacology of drugs, potentially leading to interpatient differences in response. Objective assessments of pain, sedation, and agitation have been validated for use in the ICU for assessment and titration of medications. An evidence-based strategy for administering these drugs can lead to improvements in short- and long-term outcomes for patients. In this article, we review advances in the field of ICU sedation to provide an up-to-date perspective on management of the mechanically ventilated ICU patient.

Compared with increasing sedation-analgesia, adapting the ventilator to patient breathing effort reduces breath-stacking asynchrony significantly and often dramatically. These results support an algorithm beginning with ventilator adjustment to rationalize the management of severe breath-stacking asynchrony in ICU patients.