BMI obesity and WC/WHR central obesity have a combined effect on cognitive impairment and WHR has a stronger association with cognitive impairment than WC.

Graphene oxide (GO) has been developed as an inexpensive,e nvironmental friendly, metal-free carbocatalyst for the dehydrogenation of nitrogen heterocycles.V aluable compounds,s uch as quinoline, 3,4-dihydroisoquinoline,q uinazoline,a nd indole derivatives,h aveb een successfully used as substrates.T he investigation of various oxygen-containing molecules with different conjugateds ystems indicated that botht he oxygen-containing groups and large p-conjugated system in GO sheets are essential for this reaction.

An efficient, practical, catalyst-free direct C–H trifluoromethylation of arenes using readily available and inexpensive CF3SO2Na as a CF3-source in water–acetonitrile is described.

Many techniques and strategies, such as positron emission tomography, magnetic resonance imaging, and immunohistochemistry, have been explored to diagnose tumors efficiently. [3][4][5] Among them, due to the advantages of high sensitivity, simplicity, and noninvasiveness, fluorescence molecular imaging has become a promising approach that enables detecting and visualizing the tumorrelated biomarkers in vivo. [6][7][8][9] However, tumor microenvironment (TME), as a complex system that consist of tumor cells, nearby interstitial tissues, capillaries, and various cytokines, always exhibits aberrant physiologic conditions such as low concentration of oxygen (hypoxia), acidic pH and increased interstitial fluid pressure, was still an obstacle for accurate fluorescence molecular imaging of tumor cells. [10][11][12][13][14] Accurate imaging of the dynamic changes in TME allows for the early detection of tumor and noninvasive assessment during tumor development and proliferation, and thus facilitates employing personalized therapies to improve patient survival. [15,16] To this goal, great achievements have been made to characterize dynamic changes of molecular signatures in TME. [17][18][19][20] Stimulus-responsive fluorescence imaging modality shows great promise for detection of tumor due to the advantages of high sensitivity, simplicity and noninvasiveness. However, some non-cancer regions including nodules and inflammation may also exhibit a stimulus-related characteristic, which cause the problem of nonspecific responsiveness and then cause "false positive" results for tumor recognition. Herein, hypoxia and acidic pH, two typical features strongly associated with tumor invasion, progression and metastasis in tumor microenvironment (TME), are chosen as dual stimuli to fabricate "dual lock-and-key" fluorescent nanoprobe for highly specific and precise imaging of tumor cells. Mesoporous silica coated gold nanorods (AuNR@ mSiO 2 ) are employed as nanocarrier and nanoquencher to load the pH-sensitive fluorescent reporter (Rho-TP). Azobenzene (azo) which can be reduced to amines by the highly expressed azoreductase under hypoxic conditions, is elected as the effective gatekeeper for AuNR@mSiO 2 by forming complex with β-cyclodextrin polymer via host-guest interaction (azo/β-CDP). By elaborately combining the hypoxia-responsive gatekeeper and pH-responsive fluorescent signal reporter into one nanoprobe, sensitive and specific imaging of tumor cells can be realized. The fabricated dual lock-and-key fluorescent nanoprobe successfully further apply in tumor-bearing mice model, which indicate potential of early diagnosis and assessment of cancer treatment.