The 2019 Novel Wuhan Coronavirus (2019-nCoV) epidemic (namely COVID 19) was first reported and confirmed on 31 December 2019, in Wuhan, Hubei Province, China, which is one of China's largest cities and a major domestic transport hub (located in the central part of China, as shown in Figure 1). 1 The epidemic is attracting worldwide concern due to its rapid spread and transmission rate between humans. On 30 January 2020, the International Health Regulations, Emergency Committee of the World Health Organization (WHO) declared the outbreak-a 'public health emergency of international concern'. 2 On 8 February 2020 (24:00 GMT þ 8), there were 37,198 confirmed infections in China (including 811 deaths with a death ratio of 2.1%; and 6188 patients were confirmed in serious condition and 28,942 suspected cases). 3 The COVID 19 infections were also reported in 26 other countries on

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The outbreak of pneumonia caused by 2019 Novel Coronavirus arises significant concern for virus transmission and control. The control of the indoor environment or public-enclosed environment is crucial to reduce the risk of infection. Heating, ventilation, air-conditioning (HVAC) systems are used to create a healthy, thermal-comfort indoor environments. Thus, the rational use of HVAC systems is of great importance for the environmental control to reduce infection risk and to improve human wellbeing in the pandemic. In order to satisfy the requirement of better healthy environment and more thermal comfort performance of indoor ventilation system, prevention of indoor pollution is essential, especially considering the purpose of disease transmission resistance. This paper investigated the collective contagion events in enclosed spaces as well as engineering control against virus spread with ventilation systems for health-care facilities and public vehicles. Future challenges of HVAC design and control were discussed.