Our objectives of the study is to assess the sociodemographic profile and survival profile of HIV patients. A retrospective cohort study was conducted among patients enrolled at a single antiretroviral therapy center at North Karnataka. A total of 11099 were recruited during April 2007 to January 2020. The outcome of interest was the time to death in months of HIV patients on ART. R Studio Version 1.3.1093 was used for statistical analysis. Out of 7423 HIV-positive people majority were female (51.4%), heterosexual typology (89.2%), and in the age group 31 to 45 years (45.5%). In the multivariable analysis that hazards of mortality increased by 3.11 times and 2.11 times in patients with baseline CD4 count < = 50 and baseline CD4 count 51 to 200 respectively as compared to those who had baseline CD4 count > 200. The mortality rate was high in the initial three months after the start of ART and overall survival probabilities among HIV-infected patients declined over follow-up time. This study proved that age, sex, baseline CD4 count, and TB status act as risk factors for mortality among HIV-positive individuals. Prevention strategies, control measures, and program planning should be done based on the sociodemographic determinants of mortality.
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