Natural fibers (NFs) and inorganic particles have been successfully grown in the polymer to enhance its properties. The basalt fiber (BF) and modified hydrotalcite (LDHs) reinforced epoxy resin matrix composites were prepared, and the effects of fiber and modified hydrotalcite (G-LDHs) on the microstructural characteristics of composites were investigated. Fourier transform infrared spectroscopy and X-ray diffraction were respectively used to analyze the structure of modified BF and G-LDHs, and thermogravimetric analysis was performed to study thermal stability. The mechanical properties of composites, including dynamic thermomechanical and tensile and flexural properties, were respectively studied by dynamic mechanical analysis (DMA) and universal testing machine. Experimental results show the successful synthesis of high-performance epoxy copolymers. The impact strength, tensile strength, and elastic modulus of EP/BF/G-LDHs respectively reached 7.07 kJ/m 2 , 20.52 MPa, and 2595 MPa when the content ratio of BF to hydrotalcite in the additive was 3:3. The DMA test showed that the glass transition temperature (T g ) value increased by 18.3 C, and the thermal stability of composite materials was improved. The storage modulus E 0 value increased by 268.04 MPa, and the stiffness of the epoxy material and the mechanical properties were also elevated. The TGA and DTG curves indicate that the cured composites also exhibit excellent thermal stability. The effect of g-LDHS particle size on the properties of composites was also discussed. Overall, the synergistic and complementary enhancement effect of the two materials is the best when the diameter of hydrotalcite is similar to that of BF, and the performance of the composite material is considerably improved.high-performance composites, mechanical properties, mechanical properties, thermal stability, thermogravimetric analysis | INTRODUCTIONEpoxy resin is one of the polymer materials with a long history and wide application. This material has excellent mechanical, dielectric, chemical resistance, and bonding properties. Epoxy resin can be used as coatings, casting materials, molding materials, adhesives, and laminating materials. Materials, in the form of direct or indirect use,
Ovarian cancer (OV) is a considerable threat to the health of women due to its complex mechanisms and atypical symptoms. Various currently available treatments fail to substantially increase the survival rate of OV patients. The tumor microenvironment (TME) is gaining attention due to its role in tumorigenesis and tumor progression. This study mainly investigated the immune characteristics of OV by CIBERSORT and MCP-counter. We reclassified OV into four TME cell subtypes with different prognoses and evaluated the infiltration of the cells in each subtype. The immune risk of diverse subtypes was evaluated based on the immunoscore calculated by Cox regression analysis. The molecular mechanisms and hallmark pathways of the four subtypes were analyzed. The results indicate that the immune procancer cell subtype is associated with the worst prognosis, closely related to the high immune risk group, and characterized by low expression of checkpoints and MHC class I and II molecules, high expression of hypoxia-related genes, high enrichment of the EMT and hypoxia pathways, and low enrichment of the DNA repair and interferon α response pathways. This study contributes to the investigation of immune mechanisms and identifies more effective targets for immunotherapy of OV.
Background: Endometriosis is interpreted as the existence of endometrium outside the uterine cavity, such as ovaries, fallopian tubes and pelvic cavity. Dysmenorrhea, abnormal menstruation, infertility, and chronic pelvic pain are the primary symptoms of endometriosis. Although there are many theories about the origin of endometriosis, the exact factor of the disease has not been confirmed. Therefore, many other mechanisms are still worth exploring.Materials and Methods: The gene lists of the transcription factors (TFs) were selected from the intersections of three databases. The limma R package was used to analyze the differentially expressed genes (DEGs) of GSE6364 and GSE7305 and the DEGs intersected with the TFs to obtain the differentially expressed TFs (DETFs). Subsequently, one-way ANOVA and Student's t-test were used to analyze the expression of DETFs in different phases of the endometrium and the endometrium of the infertile and fertile females with endometriosis, respectively. Enrichment analysis and PPI network were performed to reveal the molecular mechanisms of endometriosis. Finally, the plotROC R package was used to evaluate the sensitivity and specificity of hub TFs for the diagnosis of endometriosis.Results: A total of 54 DETFs were screened out in endometriosis. The expression of up-regulated DETFs was gradually increased from the early secretory to the proliferative phase of the endometrium. Most up-regulated DETFs increased expression in the endometrium of infertile females. The pathways of DETFs were mainly enriched in stem cell differentiation, transcription activity, steroid hormone receptor activity and herpes simplex virus. Two hub TFs (RUNX2 and BATF) and two sub-networks were finally acquired from the PPI network. RUNX2 and BATF also had high diagnostic value in endometriosis.Conclusion: We discovered and analyzed 54 DETFs that were closely related to endometriosis, which would contribute to explore new mechanisms of endometriosis and search for new diagnostic markers and effective therapeutic targets.
Emerging studies have clarified the critical role of LncRNA MALAT1 in various pathological progressions. Here, we identified its positive relationship with cervical carcinoma proliferation. Cervical carcinoma has been considered as one of the most malignant tumors among female. Thus, our study was designed to investigate the underlying mechanism of LncRNA MALAT1 on cervical tumor cell proliferation. We observed that miR-124 was the potential target of LncRNA MALAT1 in cervical tumor cell lines (Hela, C-33A, Caski, and SiHa), the expression level of which is negatively correlated with LncRNA MALAT1 in cervical tumor cells, tissues of cervical patients, and mice. Gain- or loss-of-function analyses in cervical tumor cells have further verified the regulatory role of MALAT1 on miR-124. Additionally, the proliferation of cervical carcinoma was inhibited by miR-124 overexpression, whereas it was blocked by LV-MALAT1 transfection. In vivo assays, overexpression of miR-124, or knockdown of MALAT1 exhibited beneficial effects on tumor weight, size, and volume, together with elevating the survival rate, tightly related with the progression of cervical cancer. In conclusion, LncRNA MALAT1 disabled the effects of miR-124 as an inhibitory sponge, accelerating the progression of cervical carcinoma.
Zinc–air batteries (ZABs) have several advantages, including high energy density, cheap price and stable performances with good application prospects in the field of power batteries. The charging and discharging reactions for the air cathode of ZABs are the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), respectively, which play an important role in the whole performance of ZAB. Due to the cost and limited reserves of highly active precious metal catalysts, it is crucial to design alternative efficient and stable dual-functional non-precious metal catalysts. In the present review, we present a systematic summary of the recent progress in the use of transition metal-based electrocatalysts as alternatives to precious metals for the positive poles of ZAB air. Combined with state-of-the-art in situ characterization technologies, a deep understanding of the catalytic mechanism of OER/ORR provided unique insights into the precise design of excellent synthetic non-precious metal catalysts from the perspective of atomic structure. This review further shows that the hybrid electric battery is a new strategy to improve the efficiency of the hybrid electric battery, which could be available to alleviate the problem of resource shortage. Finally, the challenges and research trends for the future development of ZABs were clearly proposed.
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