Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls.
MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes.
ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes.
ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.
muscle mass was not associated with physical performance in weak older adults. Measures of muscle strength may be of greater clinical importance in weak older adults than is muscle mass per se.
A series of three thiophene–naphthalene‐based asymmetric oligomers—5‐decyl‐2,2′:5′,2′′:5′′,2′′′‐quaterthiophene (DtT), 5‐decyl‐5′′‐(naphthalen‐2‐yl)‐2,2′:5′,2′′‐terthiophene (D3TN), and 5‐(4‐decylphenyl)‐5′‐(naphthalen‐2‐yl)‐2,2′‐bithiophene (DP2TN)—was synthesized by Suzuki cross‐coupling reactions. The long alkyl side chains improved both the solubility of the oligomers in solvents and their tendency to self‐assemble. UV/Vis absorption measurements suggested that DtT, D3TN, and DP2TN form H‐type aggregates with a face‐to‐face packing structure. In addition, the three oligomers were found to adopt vertically aligned crystalline structures in films deposited on substrates, as revealed by grazing‐incidence wide‐angle X‐ray scattering. These oligomers were used as the active layers of p‐type organic field‐effect transistors, and the resulting devices showed field‐effect mobilities of 3.3×10−3 cm2 V−1 s−1 for DtT, 1.6×10−2 cm2 V−1 s−1 for D3TN, and 3.7×10−2 cm2 V−1 s−1 for DP2TN. The differences in transistor performances were attributed to the degree of π overlap and the morphological differences determined by the molecular structures.
Background: The concept of frailty has been extended to include social factors such as poverty and social support networks. The frailty index developed for elderly Canadians was recently examined in terms of the current broader concept of frailty. The present study explored the relationship between social support networks and frailty in Korean elderly individuals aged 65 years or older. Methods: A total of 1,874 people aged 65 years or older were recruited by judgment sampling of the population of Seochogu in Seoul and surveyed in 2011. The Korean Frailty Index, developed by the Korean Geriatric Society, was used as an outcome variable. A proportional odds model was used to evaluate the relationship between social support networks and depressive symptoms. Results: The prevalence of frailty and pre-frailty were 7.7% and 25.5%, respectively. A total of 9.9% of older adults lacked a social network, and 13.6% were deficient in social support. Social support networks were associated with frailty. Adjusting for sociodemographic factors (age, sex, marital status, economic status, and education), lack of a social network and support were associated with increased odds of frailty (social network: odds ratio 2.15, 95% confidence interval 1.58-2.92; social support: odds ratio 2.01, 95% confidence interval 1.54-2.63). Conclusion: Consistent with the concept of frailty being broadened to include social factors, frailty among elderly individuals was found to be influenced by social support networks.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.