This clinical report presents the clinical outcome of a maxillary full‐arch implant‐supported fixed rehabilitation with lithium disilicate reinforced glass ceramic monolithic crowns opposing a mandibular metal‐acrylic implant‐supported fixed rehabilitation in a 62‐year‐old woman. Eight implants were successfully placed (four maxillary, four mandibular), and no complications occurred in the postoperative or maintenance periods. Six months after delivery, the maxillary and mandibular prostheses were found to be clinically, biologically, and mechanically stable, and the patient was satisfied with the esthetics and her ability to function. Although the present indications for the use of lithium disilicate are still restricted to tooth‐borne restorations, it is possible to successfully rehabilitate edentulous patients through implant‐supported fixed prostheses using lithium disilicate reinforced glass ceramic monolithic crowns.