PurposeHigh-intensity interval training (HIIT) appears to be safe and effective in cardiovascular diseases. However, there is a paucity of data on the effect of HIIT for patients with acute pulmonary embolism (PE). The present randomized controlled trial (RCT) therefore examined the efficiency and safety of HIIT in patients with acute PE.MethodsIn single-center parallel open-label RCT, 24 patients (5 women) discharged recently with a diagnosis of intermediate–high-risk acute PE were randomized (1:1) to supervised HIIT (n = 12) or control (n = 12) group. The primary outcomes were exercise capacity evaluated in terms of the estimated maximal oxygen uptake (eV˙O2max), lung function (forced expiratory volume in 1 s [FEV1]), right ventricular (RV) function (RV/left ventricular diameter [LV] ratio), and health-related quality of life (HRQoL). Safety was the secondary outcome.ResultsEight weeks of HIIT improved eV˙O2max (+65%, P < 0.001), FEV1 (%) (+17%, P = 0.031), and RV/LV ratio diameter (−27%, P = 0.005), as well as HRQoL. All patients in the HIIT group tolerated exercise training without serious adverse events. The control group did not improve (P > 0.05) eV˙O2max, RV/LV ratio diameter, or HRQoL; however, FEV1 (%) was slightly reduced (−6%, P = 0.030).ConclusionsThe present RCT of a tailored center-based HIIT intervention provides preliminary evidence that this intervention could improve exercise capacity, lung function, RV function, and HRQoL without serious adverse events, which could provide marked clinical benefits after PE. Further larger multicenter randomized controlled studies are needed to confirm these promising findings.
Purpose: Because of uncertainty in the pathophysiological process, the treatment of cardiac syndrome X (CSX) is still under study. Addressing the effects of cardiac rehabilitation (CR) can help promote the prescription of this modality as an adjuvant therapy for these patients. Methods: This study was performed on 30 patients with effort-induced angina pectoris using a positive exercise test and/or myocardial perfusion scan in the absence of obvious stenosis or a stenosis of <50% on coronary angiography. The patients were divided into the CR and usual care (UC) groups and underwent cardiopulmonary exercise testing with gas exchange analysis before and after the study. The Duke Treadmill Score was used to compare prognosis and survival estimates of patients. Results: An increase in peak oxygen uptake ( JOURNAL/jcprh/04.03/01273116-202001000-00008/8FSM1/v/2023-09-11T232142Z/r/image-gif o 2) was significantly higher in the CR group than in the control group (P = .017). Resting JOURNAL/jcprh/04.03/01273116-202001000-00008/8FSM1/v/2023-09-11T232142Z/r/image-gif o 2 was also increased in the CR group, but its difference with the UC group was not statistically significant. Resting O2 pulse was increased in the CR group, which significantly differed between groups (P = .041). Exercise test duration and the Duke Treadmill Score significantly increased in the CR group as compared with the UC group (P = .003 and P = .002, respectively). Also, recovery heart rate in the first minute was significantly improved in CR group. Conclusion: Adding a 4-wk course of CR to UC for patients with CSX not only increased the Duke Treadmill Score and exercise test duration but also improved the resting O2 pulse, peak JOURNAL/jcprh/04.03/01273116-202001000-00008/8FSM1/v/2023-09-11T232142Z/r/image-gif o 2, and first-minute recovery heart rate.
Introduction: The present study aimed to determine the effects of a selected group exercise on motor skills and cognitive function in children with Autism Spectrum Disorders (ASDs). Methods: Forty children with ASD aged 5-12 years participated in this quasi-experimental study. The Bruininks–Oseretsky Test of Motor Proficiency (BOTMP), and the Wisconsin Card Sorting Test (WCST) were performed in 3 assessment stages of baseline, pretest, and posttest in Sports, Play, and Active Recreation for Kids (SPARK). The repeated-measures Analysis of Variance (ANOVA) and Analysis of Covariance (ANCOVA) were used for analyzing the collected data. Results: The current research results demonstrated that the selected exercises presented positive effects on motor skills (P<0.05) in the studied subjects; however, they indicated no significant effects on their cognitive function (P>0.05). Conclusion: According to the present study results, the SPARK’s training is effective on children with ASDs and severe mobility limitations; however, it presented no cognitive function improvement in the study participants.
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