ÖZETAmaç: Bir organ kompleksi olan laboratuvar hayvanları biyomedikal çalışmalarda insanlar için model olarak kullanılmaktadır. Bu nedenle, laboratuvar hayvanlarının normal fizyolojik değerleri, sağlık durumlarıyla ilgili önemli bilgiler sağlar. Bu çalışmada da Yeni Zelanda tavşanlarının serum normal biyokimyasal değerlerinin belirlenmesi amaçlanmıştır. Yöntem: Toplam 93 (60♂; 33♀) tavşanın kulaklarından kan alındı. Serum örneklerinde biyokimyasal testler yapıldı. Analizler için biyokimyasal parametrelerin belirlenmesinde ticari teşhis kitleri kullanıldı. İstatistiksel olarak, erkek ve dişi tavşana göre değişkenlerin ortalama değerleri arasındaki fark bağımsız sample t-testi ile analiz edildi. Bulgular: Erkek tavşanların albümin, protein, CK (keratin kinaz) ve LDH (laktat dehidrogenaz) (p <0.05) değerleri dişi tavşanlara göre istatistiksel olarak anlamlı bulunmuştur. Öte yandan dişi tavşanlarda kreatinin, kolesterol ve Mg değerleri (p <0.05) önemli derecede yüksek bulunmuştur. Sonuç: Hayvanların sağlık durumlarının değerlendirilmesi için düzenli aralıklarla biyokimyasal testler yapılmalıdır. Birçok değişkene bağlı olduğundan ABSTRACT Objective: Laboratory animals, which are an organ complex, are used as model for human in biomedical studies. For this reason, information about the normal physiological values of laboratory animals provide important information on their health status. In this study, it is aimed to determine the serum normal biochemical values of New Zealand rabbits. Methods: Blood was taken from the ears of 93 rabbits. Biochemical tests were performed on serum samples. For analyses, commercial diagnostic kits were used for determination of biochemical parameters. Statistically, the difference between the mean values of the variables according to male and female rabbit was analyzed by independent sample t-test. Results: Albumin, protein, CK (creatin kinase) and LDH (lactade dehydrogenase) (p <0.05) values were found statistically significant between male and female rabbits. On the other hand, creatinine, cholesterol and Mg values (p <0.05) increased significantly in female rabbits.

The occurrence of cyanobacteria species Nodularia spumigena and its toxin nodularin were studied in Burdur Lake, a saline alkaline lake with endemic fauna and a

Encephalitozoon cuniculi can cause latent disease, especially in lagomorphs and many wild and domestic animals in various countries. This infection is important for veterinary and public health because it is caused by a potentially zoonotic and opportunistic pathogen. The aim of this study was to investigate the relationship between seropositivity of E. cuniculi and renal function markers, which may be useful in predicting the disease in clinically healthy rabbits. In this study, the seropositivity of E. cuniculi infection in clinically healthy rabbits was determined, and necropsy findings were evaluated along with the results of renal function tests. In a laboratory rabbit breeding facility, enzyme-linked immunosorbent assay (ELISA) tests showed that 48 (49.5%) of 97 rabbits were seropositive against E. cuniculi. Blood urea nitrogen (BUN) and creatinine levels were significantly elevated in seropositive animals. Two seropositive rabbits were necropsied to confirm the infection. According to histopathological findings in the kidney, degenerative changes and E. cuniculi spores were identified in the tubule epithelia. Serum creatinine (p<0.001) and BUN (p<0.01) levels were found to have a statistically significant relationship with the serological status of rabbits. Serological and histopathological methods are not routinely used in rabbits to diagnose E. cuniculi infection. The kidneys were one of the most affected organs in encephalitozoonosis in rabbits. As revealed in this study, the testing blood urea nitrogen and creatinine levels would be useful for the evaluation of general health status and renal function of the seropositive rabbits, and clinical interpretation as well.

Anaplasma phagocytophilum, the causative agent of equine granulocytic anaplasmosis, affects several species of wild and domesticated mammals, including horse, besides human. In Turkey, there were many reports on A. phagocytophilum circulation among cattles, sheep, dogs, mice, humans, except horses. In this study, we aimed to inquiry whether A. phagocytophilum were circulating among the horse population or not. For this purpose, 105 mare horse blood sera were examined for the presence of Anti-Anaplasma phagocytophilum IgG antibodies by IFAT. The seroprevalance rate of 8.57% horse sera were found to be positive. This was the first report about the presence of anti-A. phagocytophilum antibodies in horses in Turkey..

Özet: İshalli 21 buzağıda mikro COı sistemi ve kan gazı analizörü kullanılarak sırasıyla venöz kan serumu total karbondioksit ve venöz kan bikarbonat değerleri ile metabolik asidozisin şekillenip şekillenmediği saptandı. Buzağııara verilecek sodyum bikarbonat miktarı her iki yöntem kullanılarak hesaplandı. Mikro CO ı sistemi ve kan gazı analizörü ile ölçülen bikarbonat değerleri arasında istatistiksel bir fark belirlenmedi ve %75 korelasyon saptandı (r= 0,758). Sonuç olarak, ishalli buzağııara verilecek sdyum bikarbonat miktarının mikro COı sistemi ile hesaplanmasının basit ve güvenilir bir yöntem olduğu kanısına varıldı.Anahtar kelimeler: Buzağı, ishal, kan gazı analizörü, mikro CO ı sistemi Determination of metabolie acidosis and sodium bicarbonate requirement by a micro CO ı system and a blood gase analyser in diarrheic ealves Summary: Blood serum total carbondioxide and venous blood bicarbonate values and the presence of metabolic acidosis were determined by a micro COı system and a blood gase analyser respectively in 21 diarrheic calves. The requirement of sodium bicarbonate given to diarrheic calves was cakulated by using both methods. There were no statistically significant differences and 75 % correlation (r=0.758) for the values of bicarbonate between the micro CO ı system and blood gase analyser. As a result, it was conC1uded that micro COı system was a simple and a safe method for estimating the requirement of sodium bicarbonate for diarrheic calves.