Inflammation plays an important role in the pathogenesis of many cancer types and is associated with thyroid malignancy. The systemic immune-inflammation index (SII) is a new inflammation marker that can be calculated from routine complete blood count (CBC). This study investigated the association between SII, a marker derived from routine CBC, and different thyroid diseases. The objective was to determine if this simple inflammation marker can distinguish between benign and malignant thyroid diseases. The medical records of all patients who underwent surgical treatment for thyroid disease between January 2018 and January 2022 were systematically evaluated. The routine preoperative CBC parameters’ demographic, clinical, and laboratory data were recorded. A total of 241 patients were included in the study, and the patients were grouped as having multinodular goiter (n = 125), lymphocytic thyroiditis (n = 44), and papillary thyroid carcinoma (PTC) (n = 73) according to pathological results. The SII was defined as the ratio of the total count of neutrophils × platelets divided by the lymphocyte count. Subgroup analysis of patients was performed according to the presence of follicular variant or thyroiditis, micro or macro carcinoma, or bilaterality of the tumor. The SII level was significantly higher in the PTC group than in the lymphocytic thyroiditis and multinodular goiter groups (P < .001). When we grouped the patients according to the presence of PTC as benign or malignant, the optimum cutoff point for SII level was found 654.13, with 73.8% sensitivity and 72.3% specificity from ROC analysis. In the subgroup analysis of patients with PTC, the SII level was similar according to the clinicopathological characteristics of the tumor. The differential diagnosis of thyroid diseases is important for patient management. We found that preoperative SII levels were significantly elevated in patients with PTC compared to those with benign thyroid disorders, and this simple marker can be used for the differentiation of benign and malignant thyroid disease.

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Objectives: Despite strong evidence regarding the impact of radioactive iodine (RAI) on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer (DTC) patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy (Group 1; n = 33), the second group included patients with DTC who did not receive RAI following total thyroidectomy (Group 2; n = 34). The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected (Group 3; n = 37). All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI (Group 1) compared to Group 2 (those without RAI) (90.9% vs. 61.8% respectively, p = 0.003), and its prevalence in Group 3 was 54.1%. Multiple logistic regression analysis revealed that receiving RAI (OR: 4.922, 95% CI: 1.640 – 20.022, p = 0.004) was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.

Objective: We aimed to investigate Hypericum Perforatum (St. John's Wort Oil) and pure olive oil with respect to their effect on preventing intra-abdominal adhesions after abdominal surgery. Methods:This was an animal study carried out by the Giresun Faculty of Medicine, Department of General Surgery between August 10, 2020, and September 10, 2020. In the study, intra-abdominal adhesion development was examined macroscopically and microscopically on the 14th day after experimental abdominal surgery in three groups [(i) Control, (ii) olive oil application, (iii) St.John's Wort oil application] each consisting of 7 female Wistar Albino rats. Majuzi classification and Zuhlke's microscopic adhesion classification was used to evaluate adhesions.Results: Macroscopically, fibrous bands were not observed in 1 rat in the control group, 2 rats in olive oil recipients, and 1 rat in St.John's Wort oil recipients. A significant difference between the groups was identified in terms of Zuhlke's microscopic adhesion scores (p = 0.026). Accordingly, the adhesion level was significantly reduced in olive oil recipients compared to controls (p = 0.002).There was no significant difference in terms of adhesion between all groups (p>0.05). The Majuzi adhesion classifications in the control group, olive oil group and St. John's wort groups were also similar (p = 0.308). Conclusion:In rats who underwent abdominal surgery, it was determined that intra-abdominal olive oil application reduced the level of adhesion, while St. John's Wort oil application had no effect on adhesion formation.

Objective: This study aimed to investigate the association between Helicobacter pylori (H. pylori) scolonisation and ischemic hepatitis in patients with heart failure. Material Methods: A retrospective analysis was conducted on the medical records of 80 patients with heart failure who had undergone liver function tests. The patients were divided into two groups based on their liver function tests: those who developed ischemic hepatitis and those who did not. H. pylori scolonisation status was determined using serum immunoglobulin G antibody testing. Results: Of the 80 patients, 47 (58.75%) had H. pylori colonisation. H. pylori scolonisation was more prevalent in the group of patients who developed ischemic hepatitis compared to those who did not (36.2% vs 63.8%, p<0.05). These findings suggest that H. pylori scolonisation may contribute to developing ischemic hepatitis in patients with heart failure. Conclusion: This study provides evidence for an association between H. pylori scolonisation and ischemic hepatitis in patients with heart failure. The results suggest that H.pylori may contribute to this condition's development and that further research is needed to understand the mechanisms involved fully. These findings have important implications for healthcare professionals in managing heart failure and liver disease patients.