BackgroundMuscle wasting can be accelerated by chronic diseases such as heart failure and is one of the major causes of disability, morbidity, and mortality in this population. We aimed to investigate the incidence of muscle wasting and its associated factors in dilated cardiomyopathy patients younger than 55 years of age.MethodsBetween April 2014 and December 2015, all symptomatic patients with a diagnosis of non‐ischaemic dilated cardiomyopathy who were referred to heart failure clinic were included in our study.Dual energy X‐ray absorptiometry was used to evaluate body composition and identify muscle wasting. Muscle mass was calculated as the ratio of an individual's total lean mass of legs and arms (also called appendicular skeletal muscle) to their squared height (kg/m2). The muscle mass values of less than 5.45 kg/m2 for women and 7.26 kg/m2 for men were considered low.ResultsA total of 55 patients (32 male) were included. The mean (standard deviation) of age was 37.3 (10.1) years, and the mean of left ventricular ejection fraction was 21.4%. Most of the patients were in the New York Heart Association classes of II and II–III. Twenty‐six patients (47.3%) met criteria for muscle wasting. Patients with muscle wasting had lower left ventricular ejection fraction, lower 6‐min walk distance, and higher New York Heart Association function class and hospitalization rate.ConclusionsWe concluded that muscle wasting might be present in younger patients with heart failure, particularly in those who are in worse clinical condition.
Background: Several physiological and pathological processes affect the diameter of coronary arteries. It seems that the pathological increase or decrease in the size of coronary arteries is associated with cardiovascular events. Objectives: The aim of this study is to determine the relationship between the diameter of coronary arteries, gender, and traditional cardiovascular risk factors. Methods: In this cross-sectional study, we enrolled 96 patients who underwent coronary angiography at our tertiary research center. The patients' demographic data, cardiovascular risk factors, and coronary artery diameters were recorded using a digital sliding caliper. Results: Out of 96 patients with a mean age of 56.3 ± 9.8 years, 62 (64.6%) were female. Among cardiovascular risk factors dyslipidemia was the most prevalent (55 patients or 57.3%) followed by hypertension (45 patients or 46.9%) and smoking (17 patients or 17.7%). The means of the right coronary artery (RCA), left main coronary artery (LMCA), left anterior descending (LAD) and left circumflex (LCX) diameters were 3.27 ± 0.7 mm, 4.35 ± 0.7 mm, 3.5 ± 0.6 mm and 3 ± 0.7 mm, respectively. The female and participants and participants with diabetes had smaller coronary arteries: these differences have become statistically significant for LMCA and LAD in both groups (in women, the p value for LMCA and LAD were 0.04 and 0.02, respectively, and in those with diabetics, the p value for LMCA and LAD were 0.02 and 0.04, respectively). Conclusions: In our study, female participants and participants with diabetes have smaller coronary arteries. No statistically significant relationships were found between traditional coronary risk factors and the diameters of coronary arteries.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.