Scleromyxedema is a rare and distinctive variant of cutaneous mucinoses of unknown etiology. It is presenting with generalized papular eruption and sclerodermoid induration. Numerous treatment modalities have been reported to produce partial or permanent responses. This study reports on a case of scleromyxedema without paraproteinemia in a subject who experienced a partial response to thalidomide and prednisolone.

Objective: Vitiligo is an acquired depigmenting autoimmune disorder of the skin. The disease association with autoimmune diseases, such as thyroid diseases, has been reported. Previous studies among patients with vitiligo have suggested possible correlation between zinc and vitamin D levels with conflicting results. Here we compared the thyroid hormones, zinc, and vitamin D levels in patients with vitiligo with normal healthy subjects. Materials and Methods: We recruited 98 patients with vitiligo and 98 age-and sex-matched healthy subjects visiting dermatology clinics during spring and summer 2017. Serum zinc and vitamin D levels as well as thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (anti-TPO) were measured and compared between groups. Results: Patients with vitiligo had significantly lower zinc (p=0.01) and higher anti-TPO levels (p=0.02) with no difference in vitamin D (p=0.73) and TSH levels (p=0.31). Patients with vitiligo had also significantly higher rate of increased TSH (p=0.02) and positive anti-TPO (p=0.01). We observed no significant correlation between serum levels of vitamin D, zinc, and TSH with age, gender, and disease duration in patients with vitiligo. Conclusion: Patients with vitiligo, compared to healthy subjects, had lower serum zinc levels, but not vitamin D levels. Increased TSH levels were higher in patients with vitiligo with non-significantly higher anti-TPO AB as suggested to be related to autoimmune disease.

Objective: Alopecia areata is commonly associated with autoimmune disorders such as thyroid dysfunction. This paper aims to evaluate thyroid dysfunction in alopecia areata patients among the Iranian population. Material and Methods: In this case-control study, 80 alopecia areata patients were recruited along with 122 age and sex-matched healthy subjects; serum thyroid stimulating hormone and anti-thyroid peroxidase levels were then compared between the groups. Results: All alopecia areata patients had similar rate of increased thyroid stimulating hormone (10% vs. 8.2%, p=0.66) and anti-tiroid peroksidaz levels (15.6% vs. 23.8%, p=0.14) as compared to the controls. Patients with disease duration >6 months had significantly higher anti-tiroid peroksidaz levels (42.9% vs. 16.9%, p=0.01), with no difference in thyroid stimulating hormone levels (19% vs. 6.8%, p=0.1). Female patients also had higher abnormal anti-tiroid peroksidaz levels (35% vs. 12.5%, p=0.01) compared to the males. Conclusion: Thyroid stimulating hormone and thyroid antibodies are not significantly increased in alopecia areata patients when compared to the normal population. Thyroid antibodies, however, were found to be increased in females and with the progression of disease duration. Therefore, thyroid function and antibodies must be evaluated in alopecia areata patients, especially in females, and along different time periods in individuals having the disease for a long time.

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease characterized by infiltration of large mononuclear or dendritic cells in one or more organs. Lung can be involved alone or with other organs in this complication. Case Report: We report a 33-year-old smoker man with LCH in whom both the lung and the skin were involved. He was referred to our department due to malodourous, crusted and scaly erythematous patches, plaques, and pustules involved scalp and flexural area. His medical problem started with pulmonary involvement. He experienced spontaneous pneumothorax, and was suffering progressive dyspnea for years. Cryo-transbronchial lung biopsy previously had been done. Pathology report was pulmonary LCH (PLCH). Weid skin biopsy. Histologic analysis of skin with haemotoxylin and eosin (H&E) staining and immunohistochemistry (IHC) exam with S100 and CDa1 confirmed the diagnosis of LCH. Conclusion: It is important to consider PLCH in the setting of recurrent pneumothorax and progressive dyspnea in middle-aged smoker patient. PLCH may be associated with skin involvement.

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