No abstract

Abstract:Background : Severe maternal morbidity also known as 'near miss' may be a good indicator of the quality and effectiveness of obstetric care, as it may identify priorities in maternal care more rapidly than mortality alone.

A 25 years old nulliparous regularly menstruating woman presented inShSMC Hospital with the complaints of swelling in the right side of vulva and Dysparunia for 4 months. The swelling was initially small and painless but later on it became painful. The swelling recurred after surgical treatment. Examination revealed a swelling in the right Labium majus which was about 4x3 cm, bulging into right side of vagina. It was diagnosed as a case of recurrent bartholin cyst but during surgical procedure it was apparent that the swelling was not bartholin cyst but some other fleshy structure. The removed mass was 7x4 cm. Histopathology revealed benign lesion containing hypocellular structure with large blood vessels and no malignancy. It was diagnosed as Aggressive angoimyxoma. Aggressive Angoimyxoma is a very rare mesenchymal tumor, uptil now only 200 case have been reported in the world. It is a slow growing benign tumor which is typically located in the pelvis and perineum. It often presents with asymptomatic perineal or vulval mass and may be confused with Bartholin’s cyst, lipoma or hernia. Local recurrence is upto 70%; metastasis is very rare. Treatment is surgical resection Histology reveals a mass of mixed mesenchymal origin with low mitotic activity.It is a hypocellular and highly vascular tumor with myxoid stroma.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(1) : 46-48

Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because a primary etiology cannot be determined in roughly half of the instances, it is irritating for both patients and obstetricians. The present study aimed to determine the association of the antithrombin III gene (SERPINC1) mutation with unexplained RPL.Methods: This case-control observational study was conducted at the out-patient department of feto-maternal medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with a total sample size of was 68, with 34 in the control group and 34 in the case/RPL group.Results: The mean±standard deviation (SD) age of the RPL group was 28.44±5.25, and in the control group it was 29.15±4.72. The mean±SD body mass index (BMI) was 24.95±3.48 and 23.69±4.07 in RPL and control groups respectively. Among the RPL group patients, 68% (23) had the primary RPL, and 32% (11) had a second pregnancy loss.Conclusions: 5.88% of the cases have a heterozygous mutation which might be the cause of their RPL. There was no homozygous mutation was found for G878A in the case group. The allele for G878A was also higher in the case group. But these differences were statistically non-significant. So, to clarify this association with unexplained RPL, further research is necessary including multi-centre and large sample sizes.

Introduction: Recurrent pregnancy loss (RPL) is considered as a significant public health problem. In many studies, Factor V Leiden mutation is considered to have significant relationship with unexplained recurrent pregnancy loss. Aim of the study: The aim of this study was to determine the association of Factor V Leiden mutation with unexplained recurrent pregnancy loss. Methods: This case-control study was conducted in the out-patient Department of Fetomaternal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from November 2020 to April 2021 (6 months). Sample size was taken as 40 for each case and healthy control group. Result: Mean (±SD) age was found 28.2±4.9 years in RPL group and 27.1±5.24 years in non-RPL group. Maximum number of patients fell into the BMI category of 23.0-26.9 kg/m2 (BMI for Asian women) in both groups. Among the RPL cases, 30% had experienced consecutive 2 pregnancy losses with mean (±SD) number of losses 3.07±1.14. About more than half percentages (n=23, 57.5%) shared the primary RPL group. In this study, normal homozygous FVL mutation was equally distributed among RPL patients and control individuals. Only 2 cases (5%) were found positive for Factor V heterozygous mutation (GA) in the RPL group. G allele occurred in most of the cases (97.5%) of RPL. Two cases aged 25 years and 35 years respectively were found positive for heterozygous mutation of Factor V Leiden. Both of them exhibited 3 consecutive recurrent second trimester pregnancy losses. Factor V Leiden was found in higher prevalence (100%) in 2nd trimester recurrent pregnancy loss sub-group of cases and revealed significant association (p <0.001) between two variables. Conclusion: The impact of Factor V Leiden mutation has not stated any causal association with unexplained recurrent pregnancy loss. The results do not support Factor V mutation screening as an initial approach in Bangladeshi women suffering from recurrent pregnancy loss.