Abstract.To understand the different environment and morphology for heavy rainfall during 9-10 July 2007, over the Korean Peninsula, mesoscale convective systems (MCSs) that accompanied the Changma front in two different regions were investigated. The sub-synoptic conditions were analysed using mesoscale analysis data (MANAL), reanalysis data, weather charts and Multi-functional Transport Satellite (MTSAT-IR) data. Dual-Doppler radar observations were used to analyse the wind fields within the precipitation systems. During both the case periods, the surface lowpressure field intensified and moved northeastward along the Changma front. A low-level warm front gradually formed with an east-west orientation, and the cold front near the low pressure was aligned from northeast to southwest.The northern convective systems (meso-α-scale) were embedded within an area of stratiform cloud north of the warm front. The development of low-level pressure resulted in horizontal and vertical wind shear due to cyclonic circulation. The wind direction was apparently different across the warm front. In addition, the southeasterly flow (below 4 km) played an important role in generating new convective cells behind the prevailing convective cell. Each isolated southern convective cell (meso-β-scale) moved along the line ahead of the cold front within the prefrontal warm sector. These convective cells developed when a strong southwesterly low-level jet (LLJ) intensified and moisture was deeply advected into the sloping frontal zone. A high equivalent potential temperature region transported warm moist air in a strong southwesterly flow, where the convectively unstable air led to updraft and downdraft with a strong reflectivity core.
In addition to the traditional method of vaccine development, the mRNA coronavirus vaccine, which is attractive as a challenging vaccination, recently opened a new era in vaccinology. Here we describe the EG-COVID which is a novel liposome-based mRNA candidate vaccine that encodes the spike (S) protein of SARS-CoV-2 with 2P-3Q substitution in European variant. We developed the mRNA vaccine platform that can be lyophilized using liposome-based technology. Intramuscular injection of the EG-COVID elicited robust humoral and cellular immune response to SARS-CoV-2. Furthermore, sera obtained from mice successfully inhibited SARS-CoV-2 viral infection into Vero cells. We developed EG-COVID and found it to be effective based on in vitro data, and we plan to initiate a clinical trial soon. Since EG-COVID is a lyophilized mRNA vaccine that is convenient for transportation and storage, accessibility to vaccines will be significantly improved.
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