Objective: To assess reliability and discriminative validity of cartilage compositional magnetic resonance imaging (MRI) in knee osteoarthritis (OA). Design: The study was carried out per PRISMA recommendations. We searched MEDLINE and EMBASE (1974 e present) for eligible studies. We performed qualitative synthesis of reliability data. Where data from at least two discrimination studies were available, we estimated pooled standardized mean difference (SMD) between subjects with and without OA. Discrimination analyses compared controls and subjects with mild OA (KellgreneLawrence (KL) grade 1e2), severe OA (KL grade 3e4) and OA not otherwise specified (NOS) where not possible to stratify. We assessed quality of the evidence using Quality Appraisal of Diagnostic Reliability (QAREL) and Quality Assessment of Diagnostic Accuracy (QUADAS-2) tools. Results: Fifty-eight studies were included in the reliability analysis and 26 studies were included in the discrimination analysis, with data from a total of 2,007 knees. Intra-observer, inter-observer and testeretest reliability of compositional techniques were excellent with most intraclass correlation coefficients >0.8 and coefficients of variation <10%. T1rho and T2 relaxometry were significant discriminators between subjects with mild OA and controls, and between subjects with OA (NOS) and controls (P < 0.001). T1rho showed best discrimination for mild OA (SMD [95% CI] ¼ 0.73 [0.40 to 1.06], P < 0.001) and OA (NOS) (0.60 [0.41 to 0.80], P < 0.001). Quality of evidence was moderate for both parts of the review. Conclusions: Cartilage compositional MRI techniques are reliable and, in the case of T1rho and T2 relaxometry, can discriminate between subjects with OA and controls.
Understanding how people use public transport is important for the operation and future planning of the underlying transport networks. We have therefore developed and deployed a tra c measurement system for a key player in the transportation industry to gain insights into crowd behavior for planning purposes. The system has been in operation for several months and reports, at hourly intervals, (1) the crowdedness of subway stations, (2) the flows of people inside interchange stations, and (3) the expected travel time for each possible route in the subway network of Singapore. The core of our system is an e cient algorithm which detects individual subway trips from anonymized real-time data generated by the location based system of Singtel, the country's largest telecommunications company. To assess the accuracy of our system, we engaged an independent market research company to conduct a field study-a manual count of the number of passengers boarding and disembarking at a selected station on three separate days. A strong correlation between the calculations of our algorithm and the manual counts was found. One of our key findings is that travelers do not always choose the route with the shortest travel time in the subway network of Singapore. We have therefore also been developing a mobile app which allows users to plan their trips based on the average travel time between stations.
PURPOSETo compare two different methods of quantitative assessment of tibial subchondral bone in osteoarthritis (OA): statistical texture analysis (sTA) and trabecular microarchitecture analysis (tMA). METHODSAsymptomatic controls aged ͮͬ-ͯͬ (n=ͭͬ), patients aged Ͱͬ-ͱͬ with chronic knee pain but without established OA (n=ͭͬ) and patients aged ͱͱ-ʹͱ with advanced OA scheduled for knee replacement (n=ͭͬ) underwent knee MR imaging at ͯT with a ͯD gradient echo (GRE) sequence to allow sTA and tMA.tMA and sTA features were calculated using ROI creation in the medial (MT) and lateral (LT) tibial subchondral bone. Features were compared between groups using one-way ANOVA.The two most discriminating tMA and sTA features were used to construct exploratory discriminant functions to assess the ability of the two methods to classify participants. RESULTSNo tMA features were significantly different between groups at either MT or LT. ͭͳ/ͮͬ and ͭͭ/ͮͬ sTA features were significantly different between groups at the MT/LT respectively (p<ͬ.ͬͬͭ).Discriminant functions created using tMA features classified ͭͮ/ͯͬ participants correctly (Ͱͬ% accuracy, ͵ͱ% CI ͮͮ-ͱʹ%) based on MT data and ͵/ͯͬ correctly (ͯͬ%, ͭͰ-ͰͲ) based on
Background:Imaging of structural disease in osteoarthritis has traditionally relied on MRI and radiography. Joint space mapping (JSM) can quantitatively map joint space width (JSW) in three dimensions (3-D) from CT.
There is no validated radiographic measurement to diagnose prosthetic complication(s) following total ankle replacements (TAR) although a number of angular and linear measurements, used to define the TAR position on postoperative radiographs, have been recommended to detect prosthetic loosening. The aim of this study was to test the intra and interobserver reliability of these measurements. Materials and methodsThis is a prospective study embedded within a multicentre cohort study. Following sample size calculation, 62 patients were analysed. Six measurements were performed on the first postoperative anteroposterior and lateral ankle radiographs: angles α and β, and length "a" defined the craniocaudal position of the tibial component; while angle γ, lengths "b" and "c" defined the angular position of the talar component. Measurements were recorded by three independent observers. Inter and intraobserver reliability was assessed with: intraclass correlation coefficient (ICC); Bland-Altman plots; and within-subject coefficients of variation (CV). ResultsThe intrarater ICC was "almost perfect" (ICC 0.83 -0.97) for all six measurements. The interrater ICC was "substantial" to "almost perfect" (ICC 0.69 -0.93). The mean difference in intrarater angular measurements was ≤0.6 degree, and ≤0.8mm for linear measurements; ≤2.2 degrees and ≤2.1mm for interrater measurements. Maximum CV for the interrater linear measurements (≤17.7%) more than doubled that of the angular measurements (≤8.0%). The maximum width of the 95% limits of agreement was 6.5 degrees and 8.4mm for intrarater measures, and 8.9 degrees and 10.6mm for interrater measurements. ConclusionAngular measures are more reliable than linear measures and have potential in routine clinical practice for TAR position assessment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.