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The effect of screw speed (220-340 rpm), moisture content of the feed (11.0-15.0%, wet base) and feed rate (22.0-26.0 kg h )1 , wet base) on the total antioxidant capacity (TAA) and concentration of total phenolics (TP) in a nutritionally balanced extruded snack were investigated. Regression equations describing the effect of each variable on the responses were obtained. Results indicated that screw speed, moisture content of the feed and feed rate had an effect on the TAA values of the samples at 95% confidence interval (CI). The interaction between the three factors was also found to be significant at 95% CI for TAA values. Extrusion conditions applied in this study did not change the TP values in the samples. The TAA value of samples decreased with an increase in screw speed and decrease in moisture content.

The purpose of this study was to assess DNA damage levels in subjects with metabolic syndrome (MetS). Sixty-five subjects with MetS and 65 controls were enrolled in this study. Levels of DNA damage, total antioxidant capacity (TAC), total peroxide and oxidative stress index (OSI) were measured. We found that DNA damage levels were significantly increased [155.5 (60-264) vs. 93.2 (0-208) arbitrary units; p < 0.001] and TAC levels were significantly decreased in MetS than in control (1.34 +/- 0.27 vs. 55 +/- 0.33 mmol Trolox equivalent/l; p < 0.001). A significant falling trend in TAC levels and a significant rising trend in DNA damage values with the increase in the number of metabolic disturbances (anova p < 0.001 for both) were observed. Total peroxide (30.9 +/- 4.9 vs. 21.3 +/- 2.5 micromol H2O2/l; p < 0.001) and OSI levels [2.4 (1.3-3.8) vs. 1.4 (0.7-2.3) arbitrary units; p < 0.001] were significantly higher in the subjects with MetS than in controls. We found significant negative correlation between DNA damage and TAC levels in MetS (r = -0.656, p < 0.001) and in control (r = -0.546, p < 0.001). In multiple linear regression analysis, age, body mass index, presence of MetS and number of the components of MetS were independent predictors of log-transformed DNA damage (p < 0.05, for all). DNA damage is increased in patients with MetS. The increase in DNA damage might be occur because of the increase in the imbalance between the production of oxidants and antioxidant defences in subjects with MetS.

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