neoplastic and non-neoplastic tissues and when comparing the results to prevalence of ROS1 expression cited in the literature. The antibody showed expected expression of ROS1 in NSCLC, cholangiocarcinoma, melanoma, normal kidney tubules, and type II pneumocytes. The remaining cases included on the TMA were largely nonreactive. Staining performance of anti-ROS1 SP384 was consistent across 3 platforms and 3 antibody lots. Conclusions: Herein, we demonstrate that it is feasible to use anti-ROS1 SP384 to detect ROS1 protein due to the high sensitivity, specificity, and consistency of the antibody. Further studies are ongoing in previously characterized patient samples to assess antibody performance, clinical utility, and staining interpretation guidance.
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