Trifluoroacetic acid (TFA) is introduced as a commercially available, inexpensive and effective catalyst for the selective and eco-compatible synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazolesviacondensation reaction ofo-phenylenediamine derivatives and aromatic aldehydes in ethanol/water at room temperature.
A simple, efficient and clean procedure has been developed for the C-alkylation of barbituric acid. The Michael addition of barbituric acid to α,β-unsaturated esters by employing K 2 CO 3 in the nano-mordenite media (K 2 CO 3 /nano-MOR), as catalyst, gave C-alkylated barbituric acid in good to excellent yield. Nano-MOR showed good reusability. K 2 CO 3 /nano-MOR catalyst has been found to be an excellent catalyst for the reaction under solvent-free conditions at 80-90 ˚C.
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