Monitoring of physical activities is a growing field with potential applications such as lifecare and healthcare. Accelerometry shows promise in providing an inexpensive but effective means of long-term activity monitoring of elderly patients. However, even for the same physical activity the output of any body-worn Triaxial Accelerometer (TA) varies at different positions of a subject's body, resulting in a high within-class variance. Thus almost all existing TA-based human activity recognition systems require firm attachment of TA to a specific body part, making them impractical for long-term activity monitoring during unsupervised free living. Therefore, we present a novel hierarchical recognition model that can recognize human activities independent of TA's position along a human body. The proposed model minimizes the high within-class variance significantly and allows subjects to carry TA freely in any pocket without attaching it firmly to a body-part. We validated our model using six daily physical activities: resting (sit/stand), walking, walk-upstairs, walk-downstairs, running, and cycling. Activity data is collected from four most probable body positions of TA: chest pocket, front trousers pocket, rear trousers pocket, and inner jacket pocket. The average accuracy of about 95%illustrates the effectiveness of the proposed method.

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This study aimed to investigate the role of PIN1 on the hepatic differentiation of human dental pulp stem cells (hDPSCs) and its signaling pathway, as well as the potential therapeutic effects of hDPSC transplantation and PIN1 inhibition on CCl (carbon tetrachloride)-induced liver fibrosis in mice. The in vitro results showed that hepatic differentiation was suppressed by infection with adenovirus-PIN1 and promoted by PIN1 inhibitor juglone via the downregulation of Wnt3a and β-catenin. Compared with treatment with either hDPSC transplantation or juglone alone, the combination of hDPSCs and juglone into CCl-injured mice significantly suppressed liver fibrosis and restored serum levels of alanine transaminase, aspartate transaminase, and ammonia. Collectively, the present study shows for the first time that PIN1 inhibition promotes hepatic differentiation of hDPSCs through the Wnt/β-catenin pathway. Furthermore, juglone in combination with hDPSC transplantation effectively treats liver fibrosis, suggesting that hDPSC transplantation with PIN1 inhibition may be a novel therapeutic candidate for the treatment of liver injury.

We introduce some simulation and experiment results of the multichannel magnetic stimulator development that has been carried out as an initial attempt to realize a multichannel functional magnetic stimulator. For efficient functional magnetic stimulations, precise spatial localization of stimulation sites without any movements of the stimulation coils is very important. We have found that the mutual coupling effect among the adjacent stimulation coils in the coil array has to be considered in the determination of the charge voltages in some coil array configurations. Experimental results obtained with a 4-channel magnetic stimulator are presented.

In Magnetic Resonance Electrical Impedance Tomography (MREIT), we measure the induced magnetic flux density inside an imaging object subject to an external injection current. The magnetic flux density is contaminated with noise and this ultimately limits the quality of reconstructed conductivity and current density images. By using two methods to analyze amounts of noise in 3T and 11T MREIT systems, we found that a carefully designed MREIT study will be able to reduce the noise level below 0.1 nT.