The purpose of this study was to identify the relationship between the microbiological status of women and newborns, and the development of premature labor. Materials and Methods: The study included 227 pregnant women at gestational age between 28 and 36 weeks and 6 days. All women underwent an assessment of vaginal microcenosis and the quantitative and qualitative composition of the biotope of the cervical discharge; the newborns underwent bacteriological examination of the auricle, pharynx and anus. Results: Disturbances in the vaginal biotope were diagnosed in every second woman. We found that the shorter the gestation period, the higher the frequency of disturbances in the vaginal biotope, and the risk of premature birth at an earlier time correlates with the presence of infection in the mother. The risk of giving birth to an infected child is 4.2 times higher at birth from a mother who has disturbances in the biotope, compared to a woman with a normal biotope.
The aim of this study was to determine the relationship between the morpho-functional features of placentas from preterm births (PBs) with the results of bacteriological examination of the discharge from the cervical canal in women with spontaneous preterm birth (SPB). The study included 227 pregnant women at gestational age between 28 and 36 weeks and 6 days, who underwent examination in the period from 2017 to 2018. Depending on the gestational age, they were divided into 3 groups. In general, a strong relationship was found between the presence of pathological changes in placentas and the presence of opportunistic flora in women (R=0.722, P<0.001). The constructed mathematical models make it possible to determine, with a high degree of certainty, the main bacteria for all the studied groups of pregnant women, thereby identifying the risk group of women at the stage of pregnancy planning, predicting complications and increasing the possibility of deliver a full term baby.
The study demonstrated the need for topical use of Ovestin® in preoperative preparation of postmenopausal women with varying degrees of genital prolapse and stress urinary incontinence, as well as early start of administration in women during perimenopause to prevent estrogen-dependent complications and reduce the progression of the disease with minimum clinical manifestations.
Purpose. To optimize methods for the prevention of obstetric bleeding in high-risk pregnant women with abdominal delivery using the uterotonics. Material and methods. It analyzed the results of 79 pregnant women management with a high risk of obstetric bleeding who underwent delivery by caesarean section: group 1 (n = 35) standard protocol for the prevention of obstetric bleeding (oxytocin) was used; group 2 (n = 44) – carbetocin was used to prevent bleeding. The frequency of transferring patients to the so-called major operations (ligation of the internal iliac artery, the imposition of compression sutures on the uterus, supravaginal amputation of the uterus), as well as the frequency of gravitational blood surgery procedures were evaluated. Side effects were recorded against the background of the use of various options for drug support of surgical delivery. Results. It was found that the use of carbetocin as a means of preventing bleeding in women undergoing abdominal delivery contributes to a statistically significant decrease in the total frequency of bleeding after surgery compared with the use of oxytocin (1.8 times), along with a decrease in the volume of bleeding, while the frequency bleeding with a volume of more than 1500 ml decreases 2.5 times. The use of carbetocin for the prevention of bleeding in women who undergo a cesarean section contributes to a 3.1 times lower frequency of switching to performing ‘major’ operations in this category of patients compared to the use of oxytocin, as well as a decrease in the relative number of gravitational surgery procedures performed in 11,2 times. The use of carbetocin as a means of preventing bleeding in women undergoing abdominal delivery is accompanied by a lower incidence of side effects compared to the use of oxytocin (1.8 times). Conclusion. Carbetocin is one of the myometrial drugs that should be considered as a potentially important tool for improving labor outcomes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.