There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0.5% agarose. At short times (2-5 h) after gamma-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences.
The aim of this work was to investigate the dynamics of the quantity of LINE in the DNA composition of blood plasma and extrachromosomal DNA of liver cells under conditions of either immobilization or exposure to ionizing radiation or a combination of both factors. It has been established that post-stress changes in the quantity of genetic elements may be interpreted as an activation of the mechanisms of retroposition and intercellular transfer of genetic elements that ensure the formation of adaptive responses at the systemic level. The formation of adaptive responses is expressed through the reduction of the content of the low-molecular-weight fraction of the extracellular DNA.
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