Cross couplings between simple allylic
alcohols and aryl and vinyl
boronic acids are efficiently catalyzed by nickel(0) catalysts and
bidentate N-heterocyclic carbene/phosphine ligands.
The bidentate nature of the ligand is shown to extend catalyst lifetime
and enable high yields of the corresponding cross-coupling products.
X-ray crystallography confirms the bidentate nature of the ligand
scaffold. Multistep cross coupling-alkene/alkyne insertions reactions
are also conducted and the bidentate nature of the substrate makes
the pendant phosphine of the ligand unnecessary.
The design and synthesis of three organic nonlinear optical crystals is presented for terahertz (THz) generation that incorporates the optimal characteristics of known organic nonlinear optical crystals 4‐(4‐(dimethylamino)styryl)‐1‐methylpyridinium 4‐methylbenzenesulfonate (DAST) and 2‐(4‐hydroxy‐3‐methoxystyryl)‐1‐methylquinolinium 2,4,6‐trimethylbenzenesulfonate (HMQ‐TMS). The three crystals feature the 4‐((4‐(dimethylamino)phenyl)ethynyl)‐1‐methylpyridin‐1‐ium (4DEP) cation and three different anion combinations. Gas phase ab initio calculations of the cation show that 4DEP has a larger hyperpolarizability than cations from both DAST and HMQ‐TMS. To obtain the molecular packing needed for large nonlinear optical susceptibility and efficient THz generation, three anions are tested that result in noncentrosymmetric crystals: 4‐methylbenzenesulfonate, 3‐nitrobenzenesulfonate, and napthalene‐2‐sulfonate. After synthesis and crystallization, the crystal structure is characterized via X‐ray diffraction (XRD) analysis, and the relative THz generation efficiency for ideal crystals is predicted. 4DEP‐N2S shows a roughly 30% larger relative second‐order nonlinear optical susceptibility compared to HMQ‐TMS and DAST and, therefore, shows promise as a new advanced THz generation crystal.
We
report the synthesis of bimetallic Pd(I) and Pd(II) complexes
with bidentate 2-phosphinoimidazole ligands and their catalytic activity
to generate substituted naphthalenes. This process involves the coupling
of an aryl iodide and 2 equiv of a ketone via sequential ketone α-arylation
and then annulation to generate disubstituted and tetrasubstituted
naphthalenes in a regioselective manner. Excellent substrate scope
for both aryl iodide and ketone partners is demonstrated, including
that for heteroaryl iodides. Bimetallic Pd complexes are much more
reactive than monometallic Pd catalysts in this transformation. Density
functional theory calculations, isotope effect experiments, and substrate
competition experiments were used to examine bimetallic mechanisms,
reactivity, and selectivity.
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