In the recent decades, there has been widespread the opinion that genetic markers of the suicidal behavior (suicide, suicidal attempts, suicidal thoughts) can be used to predict the suicidal behavior.The purpose of the study was to determine the possibility of using the method of molecular genetic research to assess the risk of suicide in men of 18‒27 years.The study used the case-control method. The control group included 100 men of 18‒27 years who never had mental disorders. The suicide group included the persons who committed highly traumatic methods of self-harm and were motivated to commit suicide (30 persons). DNA isolation was performed using a NucleoSpin Blood kit (Macherey‒Nagel, Germany) according to the manufacturer’s protocol. Each DNA sample was analyzed for polymorphism by allelic discrimination using the real-time polymerase chain reaction (PCR).The frequencies of occurrence of genotypes and alleles of the following genes were analyzed: HTR1A, rs6295 (G/C); BDNF, rs6265 (G/A); COMT, rs4680 (G/A); SKA2, rs7208505 (C/T); SLC6A4 (5HTT), rs25531 (T/C); 5HTR2A, rs6313 (G/A); TPH2, rs4570625 (G/T); TPH1, rs1800532 (G/T).A statistically significant difference was found for the frequency of occurrence of genotypes and alleles of the rs25531 polymorphism of the SLC6A4 (5HTT) gene. The chance of being in the suicide group with a heterozygous genotype (T/C) carriage was 2.346 times higher.The significance of the rs25531 polymorphism of the SLC6A4 (5HTT) gene for the formation of the suicidal behavior was confirmed.
During the last 8 years in the city of Minsk is a series of disasters and terrorist attacks, which were accompanied by lesions of large groups of people.
Minsk city is the capital of the Republic of Belarus, in which 1 770 000 people live. Minsk had a heavy
123s the ACT/Madison-model, including case management, psychoeducation, social skills training, crisis homes, employment demands and treatment plan. Method: The baseline evaluation contained register data obtained prior to the start of the clinical study. Data included 11 ,016 admissions to mental hospitals/wards during 1981-2000 from the intervention/control region (Tonder/Aabenraa) and 868,63 1 admissions from all Denmark together with outpatient data during the period 1995-2000. Linear regression, analysis of variance and models of prediction were performed. Results: The bed rate in the SJ-county (76/100,000 December 3 1,200O) were halved during the period, corresponding to all Denmark. The increase in admission rate and decrease in bed days per admission showed homogenous pattern between intervention and control region. The country had a much higher admission rate and use of beds. The rate of involuntary admissions (0.4/1,OOO/year) and the hospital incidence of schizophrenia (1 S/l O,OOO/year) were at the same level in the intervention/control region and the country. The point prevalence and referral rates of outpatients increased to around 611,000 and 7/l ,OOO/year, respectively in both regions. One quarter of these patients belonged to the ICD-10 diagnosis F20 or F30/3 1. Conclusion: The regions of intervention and control had prior to start of ACT the same pattern of use of psychiatric services, enabling an evaluation of the effects of ACT.
Minsk population runs to 1 770 000 residents. Rather high numbers of suicidal activity were typical for Minsk, for instance, 19,7 per 100,000 people in 2003 and 15,7 per 100,000 people in 2004.Minsk is the largest industrial and cultural center Republic of Belarus, in him live 1 770 000 people. City Minsk haven't a heavy figures of suicidal activity (2003-19,7 cases per 100 000 people, 2004 - 15,7 cases per 100 000 people).To prevent suicide in Minsk a suicidal activity monitoring was conducted during two years (2005-2006) ; it included registration of all cases of suicide and parasuicide. The monitoring allowed to identify main forms of suicidal behavior, suicide methods, and sex and age-specific characteristics of suicide.It was revealed that among parasuicides prevailed women (53% of all parasuicides in 2006, 58,4% in 2005), aged 20-39 (64,6% of all parasuicides in 2006, 63% in 2005); main type of parasuicide is medicines poisoning (30% of all in 2006, 33,8% in 2005). It was established that 5 people of those who committed a parasuicide later committed suicide.Among suicides prevailed men, aged 40-59 year. Main type of suicide was hanging, 85% of all cases.The monitoring allowed to develop a strategy for prevention of suicidal behavior. The following activities were implemented:Implemented control of psychoactive drugs useOrganized collaboration with mass mediaSeminars for general practitioners were conducted with the aim of revelation of psychopathological disorders.
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