A hepta-substituted beta-cyclodextrin bearing seven amino groups, heptakis(6-amino-6-deoxy)-beta-cyclodextrin (per-6-NH2-beta-CD) was successfully used as a chiral selector for the enantioseparation of different anionic analytes. The running buffer pH and chiral selector concentration were the studied parameters crucial in achieving the maximum possible enantioresolution. Enantiomeric separation of a mixture of seven carboxybenzyl-amino acids was achieved in 24 min. Excellent resolution was obtained for carboxybenzyl-tryptophan (Rs = 11.2).

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Chitosan, obtained by deacetylation reaction of chitin, is a regular biopolymer with unique properties, including high biological and sorption activities. Melanin is considered as a natural photo and radio protector. Depending on the source and the isolation method, melanin possesses various physicochemical properties that can complement the radioprotective activity of chitosan and be used to solve important scientific and practical issues. Insects are relatively understudied natural sources of chitin-melanin complexes, whereas these components are linked by strong covalent bonds. This study developed a technology for the production of this natural conjugate, based on which its deacetylated derivative, the chitosan-melanin complex, was obtained, taking the black soldier fly as an example.

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