Punctate depressions, cartilage erosion, and bone destruction were observed in the MIA-induced arthritis model. The macroscopic cartilage and bone scoring enabled the quantification of cartilage degeneration and demonstrated that MIA-induced arthritis progressed in a dose- and time-dependent manner. IFP inflammation scores revealed that 0.2 mg MIA induced reversible synovitis, while 1 mg MIA induced fibrosis of the IFP body.

Igarashi M, Saito R, Mizukoshi K, Alford BR. Otoconia in young and elderly persons: a iemporal bone study. Acta Otolaryngol (Stockh) 1993; Suppl 504: 26-29.Using serially sectioned human temporal bones, the volumes of otoconia masses were compared between young children and elderly people. The latter group had significantly less otoconia volume than the former group, both in the macula utriculi and macula sacculi. The ratio between macula utriculi and macula sacculi was 100 : 70 in the young group, whereas it was 100 : 35 in the elderly group. Thus, the macula sacculi in the elderly group showed the severest otoconia reduction. Ke.v words: oioconia, human temporal bone, young and elderly persons. RESULTS AND DISCUSSIONIn the present study, the volume of otoconia in the macula utriculi and macula sacculi in the senile age Acta Otolaryngol Downloaded from informahealthcare.com by Nyu Medical Center on 08/02/15For personal use only.

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We developed medial meniscus extrusion in a rat model, and centralization of the extruded medial meniscus by the pull-out suture technique improved the medial meniscus extrusion and delayed cartilage degeneration, though the effect was limited. Centralization is a promising treatment to prevent the progression of osteoarthritis.