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Two acidic polysaccharides, called ginsenan S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. Meyer. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6 x 10(4) and 1.0 x 10(5), respectively. Ginsenan S-IA is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 8:8:1, and ginsenan S-IIA is composed of L-arabinose: D-galactose: D-glucose: D-galacturonic acid in the molar ratio of 15:10:2:5, in addition to small amounts of O-acetyl groups. About a half (ginsenan S-IA) and about a quarter (ginsenan S-IIA) of the hexuronic acid residues exist as methyl esters. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and periodate oxidation studies indicated that their structural features include mainly alpha-1,5-linked L-arabino-beta-3,6-branched D-galactan type structural units. Both polysaccharides showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and pronounced anti-complementary activity. These substances are the first examples having a relatively high content of both alpha-3,5-branched L-arabinose and beta-1,4-linked D-galactose units among the acidic arabinogalactans with activities on phagocytosis and anti-complement.

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An acidic polysaccharide, designated as MVS-IVA, was isolated from the seeds of Malva verticillata. It showed a remarkable reticuloendothelial system potentiating activity in the carbon clearance test. Chemical and spectroscopic studies demonstrated that the polysaccharide is rich in alpha-L-arabinofuranose residues and possesses mainly an alpha-1,5-linked L-arabino-beta-3,6-branched-D-galactan structure accompanied with rhamnogalacturonan type units. Both alpha-1,3-linked L-arabinopyranose and beta-1,4-linked D-xylopyranose residues were also identified as component units. MVS-IVA contains a small amount of protein (3.3%).