Background: Machine learning models may help localize the site of origin of ventricular tachycardia (VT) using 12-lead electrocardiograms. However, population-based models suffer from inter-subject anatomical variations within ECG data, while patient-specific models face the open challenge of what pacing data to collect for training.Methods: This study presents and validates the first hybrid model that combines population and patient-specific machine learning for rapid "computer-guided pace-mapping". A population-based deep learning model was first trained offline to disentangle inter-subject variations and regionalize the site of VT origin. Given a new patient with a target VT, an on-line patient-specific model -after being initialized by the population-based prediction --was then built in real time by actively suggesting where to pace next and improving the prediction with each added pacing data, progressively guiding pace-mapping towards the site of VT origin.
Results:The population model was trained on pace-mapping data from 38 patients and the patient-specific model was subsequently tuned on one patient. The resulting hybrid model was tested on a separate cohort of eight patients in localizing 1) 193 LV endocardial pacing sites, and 2) nine VTs with clinically determined exit sites. The hybrid model achieved a localization error of 5.3 ± 2.6 mm using 5.4 ± 2.5 pacing sites in localizing LV pacing sites, achieving a significantly higher accuracy with a significantly smaller amount of training sites in comparison to models without active guidance.
We report here on the first results of a systematic monitoring of southern glitching pulsars at the Argentine Institute of Radioastronomy that started in the year 2019. We detected a major glitch in the Vela pulsar (PSR J0835−4510) and two small-glitches in PSR J1048−5832. For each glitch, we present the measurement of glitch parameters by fitting timing residuals. We then make an individual pulses study of Vela in observations before and after the glitch. We selected 6 days of observations around the major glitch on 2021 July 22 and study their statistical properties with machine learning techniques. We use Variational AutoEncoder (VAE) reconstruction of the pulses to separate them clearly from the noise. We perform a study with Self-Organizing Maps (SOM) clustering techniques to search for unusual behavior of the clusters during the days around the glitch not finding notable qualitative changes. We have also detected and confirm recent glitches in PSR J0742−2822 and PSR J1740−3015.
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