Head and neck cancers (HNC) are extremely complex disease types and it is likely that chromosomal instability is involved in the genetic mechanisms of its genesis. However, there is little information regarding the background levels of chromosome instability in these patients. In this pilot study, we examined spontaneous chromosome instability in short-term lymphocyte cultures (72 hours) from 72 study subjects -36 newly diagnosed HNC squamous cell carcinoma patients and 36 healthy ethnic controls. We estimated chromosome instability (CIN) using chromosomal aberration (CA) analysis and nuclear level anomalies using the Cytokinesis 1123 DOI:http://dx.doi.org/10.7314/APJCP.2014.15.3.1119 Lymphocyte Nuclear Anomalies, Chromosomal Aberrations and Proliferation in Head and Neck Cancer Patients
.1119 Lymphocyte Nuclear Anomalies, Chromosomal Aberrations and Proliferation in Head and Neck Cancer Patients
Statistical analysis
Results
Clinical observations Cytogenetic study Chromosomal aberration (CA) analysis
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