AbstrakGabapentin dan pregabalin mempunyai efek antihiperalgesia, antialodinia, dan antinosiseptif untuk mengurangi nyeri pascaoperatif. Penelitian ini bertujuan untuk membandingkan gabapentin 600 mg (n=22) dengan pregabalin 150 mg (22) terhadap nyeri pascaoperatif modifikasi mastektomi radikal, yang dilakukan terhadap 44 wanita (18-65 tahun) status fisik American Society of Anesthesiologist (ASA) I-II secara uji acak terkontrol buta ganda dalam anestesi umum di Rumah Sakit Dr. Hasan Sadikin Bandung pada November 2011 sampai Maret 2012. Analisis statistik menggunakan Uji Mann-Whitney, uji-t, dan uji chikuadrat dengan tingkat kepercayaan 95% dan bermakna bila p<0,05. Penilaian skala nyeri menggunakan nilai numeric rating scale (NRS). Nilai NRS saat berbaring pada kelompok gabapentin 600 mg dan pregabalin 150 mg adalah sama (p>0,05). Nilai NRS saat mobilisasi pregabalin 150 mg lebih baik daripada gabapentin 600 mg pada tujuh dari sepuluh waktu pengukuran (p<0,05). Pemberian analgetik tambahan pascaoperatif antara kedua kelompok adalah sama (p>0,05). Simpulan, pregabalin 150 mg preoperatif lebih baik daripada gabapentin 600 mg dalam menurunkan nilai NRS pascaoperasi. Gabapentin 600 mg dan pregabalin 150 mg mampu menurunkan kebutuhan opioid pascaoperatif.Kata kunci: Gabapentin, kebutuhan analgetik opioid, numeric rating scale, nyeri pascaoperatif, pregabalin Comparison of Numeric Rating Scale Value and Post operative Opioid Requirement after Modified Radical Mastectomy between the Use of Pre-operative 600 mg Gabapentin and 150 mg Pregabalin Use AbstractGabapentin and pregabalin has anti hyperalgesia, anti allodynia, and anti nociceptive effects which lead to their use as additional medications to reduce post operative pain. This study compared the use of 600 mg gabapentin and 150 mg pregabalin in managing post-operative pain following modified radical mastectomy. The study was performed by conducting a double blind randomized controlled trial on 44 patients, aged 18-65 years old with American Society of Anesthesiologist (ASA) physical status I-II, who underwent modified radical mastectomy operation under general anesthesia, at Dr. Hasan Sadikin General Hospital Bandung during the period of November 2011 to March 2012. Patients were divided into two groups, 600 mg gabapentin (n=22), and 150 mg pregabalin (n=22) groups. The statistical analysis was conducted using Mann-Whitney Test, t-test, and chi-square test with 95% confidence interval. The results of the analysis would be considered significant if p<0.05. The quality of pain was assessed using the numeric rating scale. The NRS value at rest was similar in both groups (p>0.05). NRS during mobilization were significantly different in nine measurements (p<0.05). Total post-operative additional analgesia showed no significant difference in both groups (p>0.05). Therefore, oral preoperative 150 mg pregabalin is better than 600 mg gabapentin for reducing post-operative NRS. In addition, 600 mg Gabapentin and 150 mg pregabalin also reduce post-operative opioid consumption.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.