Bioinspired strategies have drawn much attention for designing intelligent hydrogels with promising performance. Herein, we present a bioinspired adhesive hydrogel driven by adenine and thymine, which are the basic units of DNA. The adhesive hydrogel exhibited promising adhesive property for the surface of various solid materials, including muscle tissues, plastics, rubbers, glasses, metals, ceramics, carnelians, and woods. The maximum peeling strength of hydrogels was 330 N m on aluminum, superior to that of PAAm hydrogels with 70 N m. The strong adhesive behavior remained more than 30 times repeated peeling tests. Moreover, the swelling behavior, morphological structure, mechanical strength, and peeling adhesive strength were also investigated and confirmed the formation and various characteristics of adhesive hydrogels driven by adenine and thymine. Thus, the biomimetic strategy to design promising adhesive hydrogels can provide various opportunities in tissue engineering, such as wound dressing, bioglues, and tissue adhesives.
Increased bacterial resistance to antibiotics is a major threat to human health, and it is particularly important to develop novel antibiotic drugs. Here, we designed a series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, and carried out structural characterization of the compounds and in vitro antibacterial activity tests. Compound 7e was as effective as the commonly-used antibiotic ampicillin against the Gram-negative bacterium Escherichia coli, and compound 7g had a good inhibitory effect against Gram-positive Bacillus subtilis. These ndings provide data for the development of better thiosemicarbazone antibacterial agents.
Three novel tetrathiafulvalene-annulated metalloporphyrazines with electron-withdrawing pentoxycarbonyl groups at the periphery were synthesized via the cyclotetramerization of dipentyl 6,7-dicyanotetrathiafulvalen-2,3-dicarboxylate in the presence of corresponding metal salts ( Zn(OAc)2·2H2O , Cu(OAc)2·2H2O , and NiCl2 ) and in pentanol. Molecular structures were fully characterized by 1H NMR, FT-IR, UV-vis, MALDI-TOF mass spectra and elemental analysis. These newly synthesized macrocyclic dyes were sufficiently stable in air during the purification process and also in further experiments. Electron-withdrawing substituents reduced the ability of tetrathiafulvalene groups to form radical cations. Solution electrochemical data showed one reductive and three oxidative processes within a -2000 mV to +2200 mV potential window. The four couples observed were assigned to Pz -2/ Pz -3 (I), TTF +•/ TTF (II), TTF +2/ TTF +• (III) and Pz -1/ Pz -2 (IV).
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