Background Sarcomas is a group of heterogeneous malignant tumors originated from mesenchymal tissue and different types of sarcomas have disparate outcomes. The present study aims to identify the prognostic value of immune-related genes (IRGs) in sarcoma and establish a prognostic signature based on IRGs. Methods We collected the expression profile and clinical information of 255 soft tissue sarcoma samples from The Cancer Genome Atlas (TCGA) database and 2498 IRGs from the ImmPort database. The LASSO algorithm and Cox regression analysis were used to identify the best candidate genes and construct a signature. The prognostic ability of the signature was evaluated by ROC curves and Kaplan-Meier survival curves and validated in an independent cohort. Besides, a nomogram based on the IRGs and independent prognostic clinical variables was developed. Results A total of 19 IRGs were incorporated into the signature. In the training cohort, the AUC values of signature at 1-, 2-, and 3-years were 0.938, 0.937 and 0.935, respectively. The Kaplan-Meier survival curve indicated that high-risk patients were significantly worse prognosis(P < 0.001). In the validation cohort, the AUC values of signature at 1-, 2-, and 3-years were 0.730, 0.717 and 0.647, respectively. The Kaplan-Meier survival curve also showed significant distinct survival outcome between two risk groups. Furthermore, a nomogram based on the signature and four prognostic variables showed great accuracy in whole sarcoma patients and subgroup analyses. More importantly, the results of the TF regulatory network and immune infiltration analysis revealed the potential molecular mechanism of IRGs. Conclusions In general, we identified and validated an IRG-based signature, which can be used as an independent prognostic signature in evaluating the prognosis of sarcoma patients and provide potential novel immunotherapy targets.
PurposeTo explore whether previous arthroscopic knee surgery affects future total knee arthroplasty results or not.Methods A total of 36 patients with the previous arthroscopic treatment on one knee underwent subsequent bilateral total knee arthroplasty in our hospital from September 2013 to July 2017. Data on each patient were collected in regards to changes in postoperative clinical and functional scores, various other scores, as well as postoperative functional recovery and complications. We defined the knees with a previous arthroscopic history as group A, and the counter side as group B.The Knee Society clinical score, functional scores, ROM, FJS, VAS scores were assessed before and after surgery. Using the Kolmogorov-Smirnov Test to test the normality of continuous variables, and the chi-square test to compare the rate of reoperation and complications between two groups. For all statistical comparisons, P<0.05 was considered significant.ResultsThere were no statistically significance differences found in postoperative Knee Society clinical scores and functional scores between group A and group B, as well as in ROM, FJS, VAS scores and local complications. Conclusion There were no statistically significant differences found in postoperative functional recovery and complications in patients, who underwent total knee arthroplasty with previous knee arthroscopy.
Background: To explore whether prior arthroscopic knee surgery affects future total knee arthroplasty or not Methods : A total of 36 patients with prior arthroscopy who underwent total knee arthroplasty in the department of orthopedics, affiliated hospital of Qingdao University from September 2013 to July 2017 were collected. We defined the knee with a prior arthroscopy history as group A, and the other side as group B. Using Kolmogorov-Smirnov test to test normality of continuous variables, and the chi-square test was applied to compare the rate of reoperation and complication between two groups. For all statistical comparisons, P<0.05 was considered significant. Results: There was no statistical significance in postoperative Knee Society clinical score and functional score between group A and group B, as well as ROM, FJS, VAS scores and local complications Conclusion : There were no statistically significant differences in postoperative functional recovery and complications in patients who underwent total knee arthroplasty with prior knee arthroscopy.
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