In the field of behavioral neuroscience, it is essential to use the appropriate animal models for the topic of investigation. Using the wrong model can result in false interpretation of the results. In this review we will discuss the animal models used to study sexual behavior, with a focus on rats. We will discuss the potentials and pitfalls of the different paradigms and try to make recommendations on how research in this field could be optimized. Both male and female sexual behavior are discussed, in addition to sexual motivation.

No abstract

SUMMARY BackgroundLittle is known about symptom characteristics of treated achalasia patients and their effect on health-related quality-of-life (HRQoL).

The aim of this study was to validate a translated version of an achalasia-specific quality-of-life questionnaire (achalasia-DSQoL) by examining its psychometric properties in a Dutch cohort of achalasia patients. The achalasia-DSQoL was administered to 171 treated achalasia patients together with a clinical symptom score and the RAND-36. Validation methods included factor analysis, known-group techniques, Cronbach's alpha and Spearman rank correlation with other questionnaires and feasibility. About 72.5% of the achalasia patients completed the questionnaires. The achalasia-DSQoL showed evidence of an underlying construct and seems reliable with a Cronbach's alpha of 0.77. The question concerning heartburn did not correlate with the other items on the questionnaire. Known-group techniques demonstrated that the achalasia-DSQoL discriminates between achalasia patients in clinical remission and patients who are not. There was a moderate correlation between the achalasia-DSQoL and the RAND-36 subscales. The questionnaire was easy in use. The translated version of the achalasia-DSQoL is a valid and reliable instrument to compare groups of achalasia patients although the question concerning heartburn should be excluded.

No abstract