ObjectiveWe aim to investigate whether genetic mutations in three important base excision repair genes (OGG1, APEX1, and XRCC1) may influence susceptibility to noise-induced hearing loss. MethodsThree SNPs in OGG1, APEX1, and XRCC1 were genotyped from noise exposed workers who were classified into susceptible and resistant individuals. Results: Results showed that the rs1799782 TT genotype located in the XRCC1 coding region and rs1130409 GG/GT in the APEX1 coding region were associated with increased risk for noise-induced hearing loss. Compared to the rs1799782 C allele frequency, the T allele frequency increased in the sensitive group (OR = 1.51). Rs1130409 G allele frequency also increased in the sensitive group compared to the resistant group (OR = 1.59). ConclusionsXRCC1 rs1799782 and APEX1 rs1130409 may have potential as biomarkers for screening susceptibility to NIHL in workers exposed severe noise. hearing loss in a Chinese population. International archives of occupational and environmental health 2016, 89(4):621-628. 19. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD: A generalized combinatorial approach for detecting gene-by-gene and gene-byenvironment interactions with application to nicotine dependence. American journal of human genetics 2007, 80(6):1125-1137. 20. Shi YY, He L: SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 2005, 15(2):97-98. 21. Lamerdin JE, Montgomery MA, Stilwagen SA, Scheidecker LK, Tebbs RS, Brookman KW, Thompson LH, Carrano AV: Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. Genomics 1995, 25(2):547-554. (5):801-807. 23. Hadi MZ, Coleman MA, Fidelis K, Mohrenweiser HW, Wilson DM, 3rd: Functional characterization of Ape1 variants identified in the human population. Nucleic acids research 2000, 28(20):3871-3879. 24.Au WW, Salama SA, Sierra-Torres CH: Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays.
Objective Noise-induced hearing loss (NIHL) is one of the most common occupational health risks in both developed and industrialized countries. It occurs as a result of interactions between genetic and environmental factors. Nevertheless, inherited genetic factors contributing to NIHL are not well understood. Therefore, we aim to investigate whether genetic mutations in three important base excision repair genes (OGG1, APEX1, and XRCC1) may influence susceptibility to NIHL. Methods Three SNPs in OGG1, APEX1, and XRCC1 were genotyped from 1170 noise-exposed workers and were classified into 117 most susceptible and 117 most resistant individuals. Results Results showed that the rs1799782 TT genotype located in the XRCC1 coding region and rs1130409 GG/GT in the APEX1 coding region were associated with increased risk for NIHL in a Chinese population. Compared to the rs1799782 C allele frequency, the T allele frequency was increased in the sensitive group (adjusted OR = 1.51, 95%CI = 1.01 to 2.26, P = 0.043). The rs1130409 G allele frequency was also increased in the sensitive group compared to the resistant group (adjusted OR = 1.59, 95%CI = 1.10 to 2.31, P = 0.015). Moreover, rs1130409 and drinking had a statistically significant interaction (P = 0.0002), while rs1799782, rs1130409, and smoking also had a statistically significant interaction (P < 0.0001). Conclusions XRCC1 rs1799782 and APEX1 rs1130409 may have potential as biomarkers for the screening of susceptibility to NIHL in workers exposed severe noise.
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