OBJECTIVE -To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis.RESEARCH DESIGN AND METHODS -We cross-sectionally studied 849 Japanese men aged 50.3 Ϯ 8.5 years (range 20 -78) with BMI 23.5 Ϯ 2.9 kg/m 2 . Intimal-medial thickness (IMT) of the carotid artery was measured by ultrasound. General adiposity was assessed by BMI. Waist circumference and waist-to-hip ratio (WHR) were used as a surrogate measure for abdominal fat. Abdominal subcutaneous fat area (ASF) and intra-abdominal fat area (IAF) were measured by computed tomography. Correlations between these measures and carotid IMT were analyzed. The interaction of generalized adiposity (BMI) and IAF in relation to metabolic variables, such as glucose tolerance, insulin resistance, and serum lipids, was also evaluated.RESULTS -BMI, waist circumference, WHR, ASF, and IAF were all correlated with carotid IMT. Adjustment for BMI eliminated the associations between IMT and waist circumference, ASF, and IAF. In contrast, WHR retained a significant correlation with IMT. BMI and IAF were associated with insulin resistance, glucose tolerance, HDL cholesterol, and blood pressure independently of each other. IAF was an independent correlate for serum triglyceride, but BMI was not.CONCLUSIONS -The primary importance of IAF over general adiposity for carotid atherosclerosis was not confirmed. Caution is recommended when using WHR as a measure of abdominal fat. The roles of IAF for metabolic abnormalities may be more limited than conventionally thought. BMI and WHR are simple and better clinical predictors for carotid atherosclerosis versus IAF.

Three-dimensional unsteady cavitating flow around a NACA0015 hydrofoil fixed between the sidewalls was simulated and the mechanism of U-shaped cloud cavity formation was clarified. A local homogeneous model was used for the modeling of the vaporliquid two-phase medium. The compressible two-phase Navier-Stokes equations as the governing equations were solved. To describe the phase change between water and vapor, the mass transfer model based on the theory of evaporation/condensation on a plane interface was introduced. The cell-centered finite volume method was employed to discretize the governing equations. Assuming turbulent flow, the turbulent eddy viscosity coefficient was computed by using the Baldwin-Lomax model with the Degani-Schiff modification. As a result, even in the case of cavitating flow without sidewalls, the shed cloud cavities has slightly 3D structure, which was not so much large as extending across the whole spanwise direction. On the other hand, in the case of cavitating flow with sidewalls, the end of sheet cavities bows in the spanwise direction because of the development of boundary layer near both sidewalls. After that, due to the occurring of the reentrant jet towards the mid-span region, the sheet cavities breaks off from mid-span region near the leading edge of the hydrofoil, and became the vortical cloud cavities, which have the large-scale U-shaped structure.

The data support a hypothesis that intake of fermented soy products alleviates the severity of hot flushes.

To evaluate soy intake and serum concentrations of estradiol and isoflavonoids and their relationship to bone mineral density (BMD) and serum bone-specific alkaline phosphatase (bone ALP) activity, we conducted a cross-sectional study of 87 postmenopausal Japanese women. Soy product and isoflavone intake from soy products and intake of nutrients were assessed with a semiquantitative food-frequency questionnaire. BMD (mg/cm2) was measured by single-energy X-ray absorptiometry at the site of the calcaneus. Serum estradiol (E2) and the sex hormone-binding globulin (SHBG) were measured by radioimmunoassay. Serum genistein and daidzein concentrations were measured by a high-performance liquid chromatography MS/MS method. A statistically significant correlation was observed between the ratio of E2 to SHBG and BMD (Spearman r=0.38, p=0.0003) after controlling for age, body mass index, smoking status, age at menarche, and intake of vegetable fat, vitamin C and salt. Soy product and isoflavone intake and serum isoflavones were not significantly correlated with BMD after controlling for the covariates. Serum ALP was not significantly correlated with soy product and isoflavone intake, the E2/SHBG ratio or serum isoflavones. The present study supports the association of BMD with serum estradiol; however, it does not support the association of BMD with soy or isoflavone intake or serum isoflavone levels.

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