In November 2004, 116 individuals in an elderly nursing home in El Grao de Castellón, Spain were symptomatically infected with genogroup II.4 (GII.4) norovirus. The global attack rate was 54.2%. Genotyping of 34 symptomatic individuals regarding the FUT2 gene revealed that one patient was, surprisingly, a non-secretor, hence indicating secretor-independent infection. Lewis genotyping revealed that Lewis-positive and negative individuals were susceptible to symptomatic norovirus infection indicating that Lewis status did not predict susceptibility. Saliva based ELISA assays were used to determine binding of the outbreak virus to saliva samples. Saliva from a secretor-negative individual bound the authentic outbreak GII.4 Valencia/2004/Es virus, but did not in contrast to secretor-positive saliva bind VLP of other strains including the GII.4 Dijon strain. Amino acid comparison of antigenic A and B sites located on the external loops of the P2 domain revealed distinct differences between the Valencia/2004/Es and Dijon strains. All three aa in each antigenic site as well as 10/11 recently identified evolutionary hot spots, were unique in the Valencia/2004/Es strain compared to the Dijon strain. To the best of our knowledge, this is the first example of symptomatic GII.4 norovirus infection of a Lea+b− individual homozygous for the G428A nonsense mutation in FUT2. Taken together, our study provides new insights into the host genetic susceptibility to norovirus infections and evolution of the globally dominating GII.4 viruses.

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In a recent study using a masked priming same-different matching task, Garcı´a-Orza, Perea, and Munoz (2010) found a transposition priming effect for letter strings, digit strings, and symbol strings, but not for strings of pseudoletters (i.e., EPRI-ERPI produced similar response times to the control pair EDBI-ERPI). They argued that the mechanism responsible for position coding in masked priming is not operative with those "objects" whose identity cannot be attained rapidly. To assess this hypothesis, Experiment 1 examined masked priming effects in Arabic for native speakers of Arabic, whereas participants in Experiments 2 and 3 were lower intermediate learners of Arabic and readers with no knowledge of Arabic, respectively. Results showed a masked priming effect only for readers who are familiar with the Arabic script. Furthermore, transposed-letter priming in native speakers of Arabic only occurred when the order of the root letters was kept intact. In Experiments 3-7, we examined why masked repetition priming is absent for readers who are unfamiliar with the Arabic script. We discuss the implications of these findings for models of visual-word recognition.

Numerical quantity seems to affect the response in any task that involves numbers, even in tasks that do not demand access to quantity (e.g., perceptual tasks). That is, readers seem to activate quantity representations upon the mere presentation of integers. One important piece of evidence in favor of this view comes from the finding of a distance effect in perceptual tasks: When one compares two numbers, response times (RTs) are a function of the numerical distance between them. However, recent studies have suggested that the physical similarity between Arabic numbers is strongly correlated with their numerical distance, and that the former could be a better predictor of RT data in perceptual tasks in which magnitude processing is not required (Cohen, 2009a). The present study explored the Persian and Arabic versions of Indian numbers (Exps. 1 and 2, respectively). Naïve participants (speakers of Spanish) and users of these notations (Pakistanis and Jordanians) participated in a physical same-different matching task. The RTs of users of the Indian notations were regressed on perceptual similarity (estimated from the Spanish participants' RTs) and numerical distance. The results showed that, regardless of the degree of correlation between the perceptual similarity function and the numerical distance function, the critical predictor for RTs was perceptual similarity. Thus, participants do not automatically activate Indian integers' quantity representations, at least not when these numbers are presented in simple perceptual tasks.