The thermally induced conformational switching of a stacked dialkxoynaphthalene- naphthalenetetracarboxylic diimide (DAN-NDI) amphiphilic foldamer to an NDI-NDI fibril aggregate is described. The aggregated fibril structures were explored by UV-Vis, CD, AFM and TEM. Our findings indicate that the aromatic DAN-NDI interactions of the original foldamer undergoes transformation to a fibrillar assembly with aromatic NDI-NDI stacked interactions. These structural insights could help inform new molecular designs and increase our understanding of the fibrillar assembly and aggregation process in aqueous solution.
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