Results: Metronomic CY was safe and well tolerated, and although lymphopaenia (up to grade 3) was observed in a third of all patients, there were no clinical complications.The response rate was 34.5% inclusive of objective and PSA (absolute reduction and reduction in PSA velocity). The median duration of response was 7.5 months (range 3-18 months).
Conclusions:Oral CY can be used on a metronomic basis safely in men with HRPC.The efficacy, low toxicity, low cost and ease of administration of CY justifies further studies in prostate cancer in combination with other agents.3
Purpose
Up to 38% of prostate cancer survivors experience significant psychological distress; 6–16% are diagnosed with depression or anxiety disorders. Support from a relationship partner can ameliorate psychological distress, but many studies treat relationship status as a dichotomous predictor without accounting for level of support provided by the partner.
Methods
The current study is a secondary analysis of a sample of 292 prostate cancer survivors recruited by 9 Community Clinical Oncology Program (CCOP) sites around the United States to a larger randomized controlled trial. Self-reported distress was measured at a baseline visit using the Profile of Mood States (POMS) and partner support was measured using the Social Network and Support Assessment (SNSA). Post-hoc groups consisting of unmarried survivors, married survivors with low partner support (SNSA scores below the median), and married survivors with high partner support (SNSA scores above the median) were compared on distress using univariate and ANCOVA analyses.
Results
Married prostate cancer survivors with high partner support reported significantly lower levels of psychological distress than the other two groups on the total distress scale (16.20–19.19 points lower, p<0.001). After adjusting for multiple comparisons, this pattern was also seen for subscales of distress.
Conclusions
This study highlights the importance of assessing both partner support and marital status when evaluating a survivor’s psychosocial functioning and support network.
Implications for Cancer Survivors
Assessing support could improve understanding of the association between partner support and prostate cancer survivors’ psychological distress and could lead to interventions to bolster support and reduce distress.
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