We induced in allergic humans the counterpart of murine experimental T-cell tolerance. T-cell lines from cat-allergic humans were used to map T-cell epitopes for the principal allergen of cat dander, Fel d 1. Two peptides of 27 amino acids each were synthesized to contain the dominant epitopes (ALLERVAX CAT). After a safety trial, we carried out a blinded study of the dose required for efficacy. We randomly divided 95 cat-sensitive patients into placebo, 7.5 micrograms, 75 micrograms, and 750 micrograms groups. Patients received a subcutaneous injection weekly for 4 wk. Before and after treatment, patients were exposed in a room inhabited by live cats and scored by nose and lung symptoms. Baseline nasal and lung scores (+/-SEM) were 6.2 +/- 0.56 and 5.4 +/- 0.73 in the 750 micrograms group; 7.8 +/- 0.53 and 4.7 +/- 0.68 in the placebo group. Six weeks after treatment, scores adjusted for baseline differences were reduced in the 750 micrograms group: -2.3 +/- 4.9 and -2.3 +/- 0.59 compared with -0.84 +/- 0.50 and -0.85 +/- 0.62 in the placebo group. The 75 micrograms group showed intermediate effects and the 7.5 micrograms group no effect. Linear trend analysis indicated a significant dose response effect: p = 0.05 for nose and 0.03 for lung symptoms. Allergic side effects occurred an hour or more after the first 750 micrograms dose in 16 of 24 patients but required little or no treatment with one exception. T-cell reactive treatment peptides safely improved allergic responses to cats.

A 4.9 Mkm 2 region of the southwest Pacific Ocean is made up of continental crust. The region has elevated bathymetry relative to surrounding oceanic crust, diverse and silica-rich rocks, and relatively thick and low-velocity crustal structure. Its isolation from Australia and large area support its definition as a continent-Zealandia. Zealandia was formerly part of Gondwana. Today it is 94% submerged, mainly as a result of widespread Late Cretaceous crustal thinning preceding supercontinent breakup and consequent isostatic balance. The identification of Zealandia as a geological continent, rather than a collection of continental islands, fragments, and slices, more correctly represents the geology of this part of Earth. Zealandia provides a fresh context

We use seismic reflection and rock sample data to propose that the first‐order physiography of New Caledonia Trough and Norfolk Ridge formed in Eocene and Oligocene time and was associated with the onset of subduction and back‐arc spreading at the Australia‐Pacific plate boundary. Our tectonic model involves an initial Cretaceous rift that is strongly modified by Cenozoic subduction initiation. Hence, we are able to explain (1) complex sedimentary basins of inferred Mesozoic age; (2) a prominent unconformity and onlap surface of middle Eocene to early Miocene age at the base of flat‐lying sediments beneath the axis of New Caledonia Trough; (3) gently dipping, variable thickness, and locally deformed Late Cretaceous strata along the margins of the trough; (4) platform morphology and unconformities on either side of the trough that indicate a phase of late Eocene to early Miocene uplift to near sea level, followed by rapid Oligocene and Miocene subsidence of ∼1100–1800 m; and (5) seismic reflection facies tied to boreholes that suggest absolute tectonic subsidence at the southern end of New Caledonia Trough by 1800–2200 m since Eocene time. The Cenozoic part of the model involves delamination and subduction initiation followed by rapid foundering and rollback of the slab. This created a deep (>2 km) enclosed oceanic trough, ∼2000 km long and 200–300 km across, in Eocene and Oligocene time as the lower crust detached, with simultaneous uplift and local land development along basin flanks. Disruption of Late Cretaceous and Paleogene strata was minimal during this Cenozoic phase and involved only subtle tilting and local reverse faulting or folding. Basin formation was possible through the action of at least one detachment fault that allowed the lower crust to either be subducted into the mantle or exhumed eastward into Norfolk Basin. We suggest that delamination of the lithosphere, with possible mixing of the lower crust back into the mantle, is more widespread than previously thought and may be commonly associated with subduction initiation, such as Cenozoic events in the Mediterranean and western Pacific.

No abstract

Background-Although promising results have emerged regarding oral and sublingual immunotherapy (OIT and SLIT) for the treatment of peanut allergy, direct comparisons of these approaches are limited.