BackgroundThe highly active antiretroviral therapy (HAART) has altered the course of HIV infection, transforming it from a fatal illness to a chronic condition, reducing morbidity and mortality. However, this therapy has led to an increased incidence of metabolic problems such as insulin resistance, dyslipidemia, lipodystrophy and impaired glucose metabolism.The objectives of this study are to determine the prevalence of insulin resistance (IR) in a cohort of human immunodeficiency virus (HIV)-infected patients on highly active antiretroviral therapy (HAART) and to investigate the potentially associated factors.MethodsWe conducted a cross-sectional study including 219 adult patients with HIV on HAART. IR was determined through the homeostasis model assessment (HOMA-IR) mathematical model, using fasting plasma glucose (FPG) and insulin. Bivariate and multivariate analyses were performed to assess the association between demographic information, clinical characteristics and laboratory results, and IR.Results75 (34.2 %) [95 % confidence interval (CI) 28.9–40.9] HIV-patients on HAART showed IR. 61 (81 %) of these patients were on HAART for more than one year, which was mainly composed by non-protease inhibitors drugs (88 %). Metabolic syndrome (MS) was found in 59 (26.9 %) subjects. In the multivariate analysis, the factors associated with IR were age ≥ 46 years (Prevalence ratio = 2.767, 95 % CI 1.325 to 5.780) and greater body mass index (BMI) (Prevalence ratio = 1.148, 95 % CI 1.054 to 1.250).ConclusionsThe prevalence of IR was 34.2 %. Factors associated with IR were age and BMI. We did not find any significant association between IR and protease inhibitors (PI), which may be explained by the small number of patients using PI as part of their HAART regimen included in our study.

Objetivos: Conocer el tiempo de espera para la instauración del tratamiento quirúrgico en pacientes de un hospital de tercer nivel de atención de Lima-Perú, para luego describir los factores médicos y/o administrativos que se encuentren vinculados al tiempo preoperatorio prolongado y describir las complicaciones más frecuentes durante ese tiempo. Materiales y Métodos: Estudio de tipo descriptivo – retrospectivo durante el primer semestre del 2013. Se midió los tiempos preoperatorios, complicaciones, seguro médico, antecedentes patológicos, características de la cirugía en pacientes hospitalizados con fractura de cadera. Resultados: El 71% de pacientes fue de sexo femenino. La mediana de edad fue de 66 años. El 70% de pacientes recibió tratamiento quirúrgico con una mediana del tiempo preoperatorio de 18 días. El 77% tuvo antecedentes patológicos al ingreso, la mayoría por anemia, hipertensión arterial o diabetes mellitus tipo 2. El 62% tuvo complicaciones médicas. Los pacientes con tratamiento quirúrgico tuvieron menos porcentaje de complicaciones (47%) que los que no recibieron tratamiento quirúrgico (94%), así como menos estancia hospitalaria. La mediana de estancia hospitalaria enlos pacientes con tratamiento quirúrgico fue de 26 días y la de los que no recibieron tratamiento quirúrgico fue 41 días. Conclusiones: El tiempo preoperatorio fue mayor a las 2 semanas en la mayoría de los casos, especialmente en los pacientes de mayor edad y usuarios del Seguro Integral de Salud.

AimWe aimed to estimate the morbidity rate and associated factors for diabetic peripheral neuropathy (DPN) in a low-middle income country setting.MethodsCross-sectional study, data was gathered at Peru's Ministry of Health national specialized hospital for endocrinological conditions through standardized interviews, anthropometric measurements and blood tests for glycated haemoglobin (HbA1c). DPN was evaluated using two techniques: the Semmes-Weinstein monofilament test and the diabetic neuropathy symptom score. Overall prevalence and 95% confidence intervals (95% CI) were calculated. Potential factors related to DPN explored included body mass index, years with disease (<10 vs. ≥10 years), glycaemic control (HbA1c <7% vs. ≥7%), microalbuminuria, retinopathy, and current pharmacological treatment. Multivariable analysis was performed using Poisson analysis to calculate prevalence ratios.ResultsDPN was observed in 73/129 (56.6%) patients. In multivariable analysis adjusted by age and sex, the prevalence ratio of neuropathy was 1.4 times higher (95% CI 1.07–1.88) in patients who took insulin plus metformin compared to patients who used one treatment alone, and 1.4 higher (95% CI 1.02–1.93) in patients with ≥10 years of disease compared to those with a shorter duration of disease. Also we found some characteristics in foot evaluation associated to neuropathy such as deformities (p<0.001), onychomycosis (p = 0.012), abnormal Achilles reflex (p<0.001), pain perception (p<0.001) and vibration perception (p<0.001).ConclusionDPN is highly frequent among patients with diabetes in a national specialized facility from Peru. Associated factors to DPN included being a diabetic patient for over ten years, and receiving insulin plus metformin