We report synthesis of histamine-and imidazole-4-propionic acid-based ionic liquids containing a variety of alkyl and aryl groups placed at the two different positions of the constituent imidazole ring in convenient steps in good yields.
Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present study was to develop pectin or gellan gum blended sodium alginate microspheres in order to eradicate gastric Helicobacter pylori. The percentage drug release and mucoadhesion were decrease on increasing the calcium chloride in the formulation dispersion. Curing time significantly effected encapsulation efficiency and was not affected % drug content, % buoyancy, and particle size and drug release. The efficacy of the optimized formulation was evidenced by absence of amplified bacterial gene in treated stomach tissue of Mongolian gerbils as observed using in polymerase chain reaction. The results demonstrate that the developed formulation of Am has potential to eradicate Helicobacter pylori by targeted and prolonged retention at gastric mucosa.
Assessment of water quality of drinking water supplies has always been paramount in the field of environmental quality management. Groundwater quality of Dwarka has a special significance and needs greater attention of all concerned since it is the only major source for domestic, consumption. In this work we have estimated the ground water quality of Dwarka. Groundwater quality of Delhi needs greater attention because there is a continuous decline in water level and quality due to rapid urbanization and industrialization. The present study was attempted to access the groundwater quality of Dwarka district in Delhi. The samples of the ground water are collected manually from the bore wells which were approximately equally distributed all over 29 sectors and nearby areas. The samples were analyzed using standard procedures in the laboratory. The water quality index is a single number that expresses the quality of water by integrating the water quality variables. Its purpose is to provide a simple and concise method for expressing the water quality for different usage. Water Quality Index, has been calculated for the Dwarka sub-city and was studied for the suitability of water for drinking purposes and the results showed that the ground water quality was unfit for drinking in almost all of the areas scoring a water quality index greater than 110.
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