The authors compared ultrasonography with electrophysiology for the diagnosis of carpal tunnel syndrome (CTS) on 110 clinically affected wrists. An increased cross sectional area in the proximal carpal tunnel larger than 0.11 cm(2) in combination with compression signs on longitudinal scans proved to be highly predictive for CTS (sensitivity, 89.1%; specificity, 98.0%). Ultrasound was comparable to electrophysiology in the diagnosis of CTS, and in 35% of cases changes in morphology suggested a specific therapeutic strategy.
The rare case of a patient with carpal tunnel syndrome caused by thrombosis of a persistent median artery is presented. Progressive pain in the wrist and dysesthesias in the third and fourth fingers were the atypical complaints. High-resolution ultrasonography revealed a bifid median nerve that was compressed by an occluded median artery. The intraoperative findings are described, and emphasis is placed on the importance of using high-resolution ultrasonography for presurgical diagnosis.
1 Release of CGRP during migraine may produce harmful dilatation of cranial arteries, thereby possibly causing pain. We have compared the antagonism by BIBN4096BS and CGRP(8-37) of the relaxant eects of a-CGRP on rings of human temporal artery. 2 a-CGRP relaxed the arteries precontracted with 9 ± 24 mM KCl (7logEC 50 =9.4) nearly as ecaciously as sodium nitroprusside (10 mM). 3 BIBN4096BS (0.1 ± 100 nM) antagonized the eects of a-CGRP in surmountable manner with slopes of Schild-plots not dierent from unity. 7LogK B values of 10.1 and 10.4 were estimated for BIBN4096BS when administered before or during the KCl-contracture respectively. 4 BIBN4096BS (1 mM) did not modify the relaxant eects of papaverine and sodium nitroprusside. 5 CGRP(8-37) (1 ± 10 mM) antagonized the eects of a-CGRP in a surmountable manner with slopes of Schild-plots not dierent from unity. 7LogK B values of 6.6 and 6.7 were estimated for CGRP(8-37) administered before or during the KCl-contracture respectively. 6 The high anity of BIBN4096BS for CGRP receptors of human temporal artery makes it an excellent tool to explore the hypothesis of CGRP-evoked cerebral vasodilation in migraine.
1 In the human temporal artery both 5-HT 1-like and 5-HT 2A receptors mediate the contractile eects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT 1-like receptors resemble more closely recombinant 5-HT 1B than 5-HT 1D receptors. To investigate further which subtype is involved, we investigated the blockade of 5-HT-induced contractions by the 5-HT 1B -selective antagonist SB-224289 (2,3,6,7-tetrahydro-1'-methyl-5-{2-methyl-4'[(5-methyl-
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.