Several organizations issued recommendations on desirable serum 25-hydroxy vitamin D [25(OH)D] levels and doses of vitamin D needed to achieve them. Trials allowing the formulation of evidence-based recommendations in adolescents are scarce. We investigated the ability of two doses of vitamin D 3 in achieving recommended vitamin D levels in this age group. Post hoc analyses on data from a 1-year double-blind trial that randomized 336 Lebanese adolescents, aged 13 AE 2 years, to placebo, vitamin D 3 at 200 IU/ day (low dose), or 2000 IU/day (high dose). Serum 25(OH)D level and proportions of children achieving levels !20 ng/mL and 30 ng/ mL were determined. At baseline, mean 25(OH)D was 15 AE 7 ng/mL, 16.4 AE 7 ng/mL in boys, and 14 AE 8 ng/mL in girls, p ¼ 0.003, with a level !20 ng/mL in 18% and !30 ng/mL in 5% of subjects. At 1 year, mean levels were 18.6 AE 6.6 ng/mL in the low-dose group, 17.1 AE 6 ng/mL in girls, and 20.2 AE 7 ng/mL in boys, p ¼ 0.01, and 36.3 AE 22.3 ng/mL in the high-dose group, with no sex differences. 25(OH)D increased to !20 ng/mL in 34% of children in the low-dose and 96% in the high-dose group, being higher in boys in the lowdose arm only; it remained !30 ng/mL in 4% of children in the low-dose arm but increased to 64% in the high-dose arm. Baseline 25 (OH)D level, body mass index (BMI), and vitamin D dose assigned were the most significant predictors for reaching a 25(OH)D level !20 ng/mL and 30 ng/mL. A daily dose of 2000 IU raised 25(OH)D level !20 ng/mL in 96% of adolescents (98% boys versus 93% girls). Dose-response studies are needed to determine in a definitive manner the daily allowance of vitamin D for Middle Eastern adolescents with a similar profile.
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